Results 11 to 20 of about 5,307 (166)
Exploring Metabolic Pathways of Anamorelin, a Selective Agonist of the Growth Hormone Secretagogue Receptor, via Molecular Networking [PDF]
Pharmaceutics, 2023 In this study, we delineated the poorly characterized metabolism of anamorelin, a growth hormone secretagogue receptor agonist, in vitro using human liver microsomes (HLM), based on classical molecular networking (MN) and feature-based molecular ...
Young Beom Kwak +2 more
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The growth hormone secretagogue receptor: its intracellular signaling and regulation. [PDF]
Int J Mol Sci, 2014 The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion ...
Yin Y, Li Y, Zhang W.
europepmc +4 more sources
Growth hormone secretagogue receptor is important in the development of experimental colitis. [PDF]
Cell Biosci, 2015 Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role of GHSR in the development of colitis is unclear.
Liu ZZ +9 more
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Development and Characterization of an F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor [PDF]
Molecular Imaging, 2018 One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular abnormalities ...
Ahmed Abbas MSc +6 more
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The ups and downs of growth hormone secretagogue receptor signaling [PDF]
The FEBS Journal, 2021 The growth hormone secretagogue receptor (GHSR) has emerged as one of the most fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth hormone secretion but also food intake, adiposity, body weight, glucose homeostasis and other complex
María P. Cornejo +5 more
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Adenosine Is an Agonist of the Growth Hormone Secretagogue Receptor [PDF]
Endocrinology, 2000 Growth hormone secretagogues (GHSs) are synthetic compounds that induce GH release in several species, including man. The aim of the current study was to identify hypothalamic GHS receptor (GHS-R) agonists. This led to the discovery of adenosine as a GHS-R agonist.
S, Tullin +5 more
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Endocrinology Research and Practice, 2022 Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that has recently been isolated from the ...
Serdar Güler +2 more
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Ghrelin and the growth hormone secretagogue receptor in growth and development [PDF]
International Journal of Obesity, 2009 The pancreas is a major source of ghrelin in the perinatal period, whereas gastric production progressively increases after birth. Loss of function of the genes for ghrelin or for the constitutively activated growth hormone secretagogue receptor (GHSR) does not affect birth weight and early postnatal growth.
J-P, Chanoine, K, De Waele, P, Walia
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Growth hormone secretagogues: history, mechanism of action, and clinical development
JCSM Rapid Communications, 2020 Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida +5 more
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The growth hormone secretagogue receptor
Growth Hormone & IGF Research, 1999 The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
Korbonits, M +3 more
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