Results 31 to 40 of about 5,307 (166)

Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain

Frontiers in Endocrinology, 2014
The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern, Cristina eGrande, Roy G Smith   +2 more
doaj   +1 more source

Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction

Biomolecules, 2022
Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be further illuminated, in particular with regard to the structural impact of GPCR C ...
Myriam Guillien, Assia Mouhand, Aurélie Fournet, Amandine Gontier, Aleix Martí Navia, Tiago N. Cordeiro, Frédéric Allemand, Aurélien Thureau, Jean-Louis Banères, Pau Bernadó, Nathalie Sibille   +10 more
doaj   +1 more source

A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia

Advanced Science, 2023
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood.
Tingting Yi, Na Wang, Jing Huang, Yaling Wang, Shuancheng Ren, Yiwen Hu, Jianxia Xia, Yixiang Liao, Xin Li, Fenlan Luo, Qin Ouyang, Yu Li, Ziyi Zheng, Qin Xiao, Rong Ren, Zhongxiang Yao, Xiangdong Tang, Yanjiang Wang, Xiaowei Chen, Chao He, Hong Li, Zhian Hu   +21 more
doaj   +1 more source

Ghrelin

Molecular Metabolism, 2015
Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the ...
T.D. Müller, R. Nogueiras, M.L. Andermann, Z.B. Andrews, S.D. Anker, J. Argente, R.L. Batterham, S.C. Benoit, C.Y. Bowers, F. Broglio, F.F. Casanueva, D. D'Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P.A. Cole, M. Cowley, D.E. Cummings, A. Dagher, S. Diano, S.L. Dickson, C. Diéguez, R. Granata, H.J. Grill, K. Grove, K.M. Habegger, K. Heppner, M.L. Heiman, L. Holsen, B. Holst, A. Inui, J.O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C.W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P.T. Pfluger, T.W. Schwartz, R.J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M.O. Thorner, A.J. van der Lely, L.H.T. van der Ploeg, J.M. Zigman, M. Kojima, K. Kangawa, R.G. Smith, T. Horvath, M.H. Tschöp   +56 more
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Effect of Ghrelin on the Cardiovascular System

Biology, 2022
Ghrelin, an n-octanoyl-modified 28-amino-acid-peptide, was first discovered in the human and rat stomach as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Ghrelin-GHS-R1a signaling regulates feeding behavior and energy balance,
Hiroshi Hosoda
doaj   +1 more source

Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus [PDF]

Endocrinology, 1998
A novel class of synthetic compounds, termed GH-secretagogues (GHSs), have been shown to be potent stimulators of GH release, although their mechanism of action and functional significance remains obscure. The recent cloning of the rat GHS receptor (GHS-R) permitted the identification of numerous sites of expression of GHS-R in brain, but nothing is ...
G S, Tannenbaum, M, Lapointe, A, Beaudet, A D, Howard   +3 more
openaire   +2 more sources

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity [PDF]

Journal of Clinical Investigation, 2002
Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach.
Yujin, Shuto, Tamotsu, Shibasaki, Asuka, Otagiri, Hideki, Kuriyama, Hisayuki, Ohata, Hideki, Tamura, Jun, Kamegai, Hitoshi, Sugihara, Shinichi, Oikawa, Ichiji, Wakabayashi   +9 more
openaire   +2 more sources

How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

Frontiers in Molecular Neuroscience
Ghrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura, Yuki Shiimura, Masayasu Kojima, Takahiro Sato   +3 more
doaj   +1 more source

Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues [PDF]

Molecular Endocrinology, 1998
AbstractAntibodies raised against an intracellular and extracellular domain of the GH secretagogue receptor (GHS-R) confirmed that its topological orientation in the lipid bilayer is as predicted for G protein-coupled receptors with seven transmembrane domains.
S D, Feighner, A D, Howard, K, Prendergast, O C, Palyha, D L, Hreniuk, R, Nargund, D, Underwood, J R, Tata, D C, Dean, C P, Tan, K K, McKee, J W, Woods, A A, Patchett, R G, Smith, L H, Van der Ploeg   +14 more
openaire   +2 more sources

Effects of Astragalus Extract Mixture HT042 on Circulating IGF-1 Level and Growth Hormone Axis in Rats

Children, 2021
Astragalus extract mixture HT042 is a standardized functional food granted by the Korean FDA for promoting “Children’s Height Growth”. In this study, we determined whether HT042 affects circulatory Insulin-like growth factor-1 (IGF-1) after ...
Donghun Lee, Byung-Hak Kim, Sung-Hyun Lee, Won-Young Cho, Young-Sik Kim, Hocheol Kim   +5 more
doaj   +1 more source