Results 51 to 60 of about 5,307 (166)

The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis [PDF]

Endocrinology, 2003
Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-activated receptor gamma 2 (PPAR ...
Choi, Kichoon, Roh, Sang-Gun, Hong, Yeon-Hee, Shrestha, Yogendra B, Hishikawa, Daisuke, Chen Chen, Kojima, Masayasu, Kangawa, Kenji, Sasaki, Shin-Ichi   +8 more
openaire   +5 more sources

Alcohol Exposure Alters the Ghrelin System: In Vitro Mechanistic Insights Into Impaired Glucose Sensing and Enhanced Ghrelin Secretion

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Chronic ethanol exposure increases ghrelin production by impairing glucose sensing in ghrelin‐secreting cells. Ethanol elevates ghrelin and ghrelin O‐acyltransferase expression, blunts glucose‐mediated suppression, and synergizes with fatty acids to enhance secretion.
Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K. Kharbanda, Ojeshvi Ethiraj, Carol A. Casey, Karuna Rasineni   +5 more
wiley   +1 more source

Sodium is a negative allosteric regulator of the ghrelin receptor

Cell Reports, 2023
Summary: The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment.
Guillaume Ferré, Antoniel A.S. Gomes, Maxime Louet, Marjorie Damian, Paulo M. Bisch, Olivier Saurel, Nicolas Floquet, Alain Milon, Jean-Louis Banères   +8 more
doaj   +1 more source

Lean, Non‐Autoimmune Young‐Onset Diabetes in Bangladesh: A Metabolically Obese Phenotype With Disproportionate Insulin Secretory Defect

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Lean young‐onset diabetes in Bangladeshi adults showed marked estimated β‐cell dysfunction, high glycemic burden, modest insulin resistance, and dyslipidemia despite non‐obese BMI. These findings highlight the need for assessment beyond BMI‐based classification and individualised management.
Mashfiqul Hasan, Nusrat Sultana, Kishore Kumar Shil, Sayad Bin Abdus Salam, Koushik Ashraf, Abdullah Al Noman Bhuiyan, Md. Omor Al Masud, Rifat Hossain Ratul, Muhammad Abul Hasanat   +8 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

BMC Gastroenterology, 2010
Background Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake.
Engel Christoph, Kloor Matthias, Betz Beate, Kötting Judith, Görgens Heike, Schackert Hans K, Morak Monika, Holinski-Feder Elke, Rahner Nils, Steinke Verena, Novotny Jan, Vodickova Ludmila, Naccarati Alessio, Pardini Barbara, Campa Daniele, Büttner Reinhard, Propping Peter, Försti Asta, Hemminki Kari, Barale Roberto, Vodicka Pavel, Canzian Federico   +21 more
doaj   +1 more source

Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.
Nazli Khatib, Shilpa Gaidhane, Abhay M Gaidhane, Mahanaaz Khatib, Padam Simkhada, Dilip Gode, Quazi Syed Zahiruddin   +6 more
doaj   +1 more source

TBC1D4‐Related Monogenic Diabetes: Molecular Mechanisms, Clinical Recognition, and Therapeutic Implications

Journal of Diabetes, Volume 18, Issue 8, August 2026.
TBC1D4‐related monogenic diabetes is characterized by defective AS160‐mediated GLUT4 trafficking, skeletal muscle insulin resistance, and predominant postprandial hyperglycemia. Clinical recognition relies on atypical young‐onset diabetes with marked insulin resistance, followed by genetic confirmation and individualized management.
Wenjing Wang, Lidan Ma, Bingzi Dong, Peihan Gao, Xiaofang Sun   +4 more
wiley   +1 more source

Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5779-5786, July 2026.
ABSTRACT Aims To evaluate the effects of premeal versus postmeal metformin administration on postmeal glycemic control in individuals with type 2 diabetes mellitus receiving metformin monotherapy. Methods All participants were randomly assigned to receive immediate‐release metformin either 30–60 min before or immediately after meal for 4 weeks, and ...
Issaree Rattarasarn, Chatvara Areevut, Khaimook Prachakeserane, La‐Or Chailurkit, Chutintorn Sriphrapradang, Chatchalit Rattarasarn   +5 more
wiley   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, Volume 56, Issue 7, Page 1126-1133, July 2026.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source