Results 61 to 70 of about 6,273,650 (192)

Recent Advances in Potential Clinical Application of Ghrelin in Obesity

Journal of Obesity, 2012
Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelin O-acyltransferase (GOAT).
Christine Delporte
doaj   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Pilot Study of a Herbal Formulation Composed of Bidens pilosa for Constipation in Humans

eFood, Volume 7, Issue 5, October 2026.
ABSTRACT The gut microbiota and their metabolites are associated with constipation and other gastrointestinal diseases. Dietary phytochemicals are crucial factors shaping gut microbiota. Here, we conducted a first‐in‐human trial of the herbal formulation BP, composed of a Bidens pilosa extract and excipient, in volunteers with constipation.
Tien‐Fen Kuo, Yi‐San Lee, Greta Yang, Yu‐Chuan Liang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Ghrelin Alleviates Aging‐Related Cognitive Impairment by Regulating Autophagy‐Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia

Aging Cell, Volume 25, Issue 10, October 2026.
This study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Lixing Zhou, Ying Cheng, Wanyu Zhao, Xuelian Sun, Fengjuan Hu, Meiling Ge, Yan Zhang, Gongchang Zhang, Birong Dong, Xiaolei Liu   +9 more
wiley   +1 more source

2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists

, 2016
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents.
Lissa T. J. Nelson (2507350), David W. A. Beno (2110654), Mei Liu (41760), Hongyu Zhao (4728), Eugene N. Bush (2533909), Zhili Xin (1909210), Gang Liu (81776), H. Douglas Falls (2533888), Michael D. Serby (2486734), Verlyn Schaefer (2642959), Brian A. Droz (2510449), Robin Shapiro (2521357), Christine A. Collins (2110648), Wiweka Kaszubska (2642965), Michael E. Brune (2110702), Peer B. Jacobson (2510416), Bo Liu (127343), Victoria E. Knourek-Segel (2533894), Theresa M. Turner (2642962), Bruce G. Szczepankiewicz (2047120), Hing L. Sham (2126860), Christi Kosogof (2533891), Thomas A. Fey (2465779)   +22 more
core   +1 more source

Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Early‐life exposure to metabolic hormones may influence the development of taste acceptance and subsequent intake of hyperpalatable foods (HPF) in infants, but evidence integrating hormonal, behavioral, and dietary data in humans is limited.
Ana Luz Kruger, Agustina Malpeli, Marisa Sala, Carla Casado, Ignacio Mendez, Lucrecia Fotia, Mercedes López, María Silvina Faquini, Daniel Castrogiovanni, Helgi Schioth, Sophie Nicklaus, Mario Perello, María F. Andreoli   +12 more
wiley   +1 more source

Effect of unacylated ghrelin on peripheral nerve regeneration

European Journal of Histochemistry, 2021
Ghrelin is a circulating peptide hormone released by enteroendocrine cells of the gastrointestinal tract as two forms, acylated and unacylated. Acylated ghrelin (AG) binds to the growth hormone secretagogue receptor 1a (GHSR1a), thus stimulating food ...
Giulia Ronchi, Pierluigi Tos, Elia Angelino, Luisa Muratori, Simone Reano, Nicoletta Filigheddu, Andrea Graziani, Stefano Geuna, Stefania Raimondo   +8 more
doaj   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Discovery of Tetralin Carboxamide Growth Hormone Secretagogue Receptor Antagonists via Scaffold Manipulation

, 2016
A case study of rational design of an efficient, specific, and proprietary molecular scaffold based on the structure−activity relationship (SAR) information on a screening hit is described.
Christine A. Collins (2110648), Wiweka Kaszubska (2642965), Hongyu Zhao (4728), Zhili Xin (1909210), Gang Liu (81776), H. Douglas Falls (2533888), Hing L. Sham (2126860), Verlyn G. Schaefer (2698198)   +7 more
core   +2 more sources

The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 72-78).The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive ...
Phillips, Pumza Samantha
core   +1 more source