Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors [PDF]
Molecular Endocrinology, 1997 GH release is thought to occur under the reciprocal regulation of two hypothalamic peptides, GH releasing hormone (GHRH) and somatostatin, via their engagement with specific cell surface receptors on the anterior pituitary somatotroph. In addition, GH-releasing peptides, such as GHRP-6 and the nonpeptide mimetics, L-692,429 and MK-0677, stimulate GH ...
Karen K. McKee +8 more
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Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease [PDF]
CJC Open, 2021 Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc +7 more
doaj +2 more sources
Exploring Metabolic Pathways of Anamorelin, a Selective Agonist of the Growth Hormone Secretagogue Receptor, via Molecular Networking [PDF]
Pharmaceutics, 2023 In this study, we delineated the poorly characterized metabolism of anamorelin, a growth hormone secretagogue receptor agonist, in vitro using human liver microsomes (HLM), based on classical molecular networking (MN) and feature-based molecular ...
Young Beom Kwak +2 more
doaj +2 more sources
Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation [PDF]
Molecular MetabolismObjective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim +13 more
doaj +2 more sources
The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin [PDF]
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
doaj +2 more sources
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor [PDF]
Proceedings of the National Academy of Sciences, 2004 Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of tissue extracts in a cell line engineered to overexpress the GHSR led to the identification of a natural agonist called ghrelin.
Yuxiang Sun +3 more
openalex +5 more sources
Growth hormone secretagogue receptor is important in the development of experimental colitis. [PDF]
Cell Biosci, 2015 Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role of GHSR in the development of colitis is unclear.
Liu ZZ +9 more
europepmc +5 more sources
Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus [PDF]
Endocrinology, 1998 A novel class of synthetic compounds, termed GH-secretagogues (GHSs), have been shown to be potent stimulators of GH release, although their mechanism of action and functional significance remains obscure. The recent cloning of the rat GHS receptor (GHS-R) permitted the identification of numerous sites of expression of GHS-R in brain, but nothing is ...
Gloria S. Tannenbaum +3 more
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The growth hormone secretagogue receptor: its intracellular signaling and regulation. [PDF]
Int J Mol Sci, 2014 The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion ...
Yin Y, Li Y, Zhang W.
europepmc +5 more sources
How the ghrelin receptor recognizes the acyl-modified orexigenic hormone [PDF]
Frontiers in Molecular NeuroscienceGhrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura +3 more
doaj +2 more sources