Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens [PDF]
Molecular BrainThe potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in regulating drug addiction and feeding has been documented; however, the pattern of its expression in this ...
Seohyeon Lee +3 more
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Exploring Metabolic Pathways of Anamorelin, a Selective Agonist of the Growth Hormone Secretagogue Receptor, via Molecular Networking [PDF]
Pharmaceutics, 2023 In this study, we delineated the poorly characterized metabolism of anamorelin, a growth hormone secretagogue receptor agonist, in vitro using human liver microsomes (HLM), based on classical molecular networking (MN) and feature-based molecular ...
Young Beom Kwak +2 more
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Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus [PDF]
Endocrinology, 1998 A novel class of synthetic compounds, termed GH-secretagogues (GHSs), have been shown to be potent stimulators of GH release, although their mechanism of action and functional significance remains obscure. The recent cloning of the rat GHS receptor (GHS-R) permitted the identification of numerous sites of expression of GHS-R in brain, but nothing is ...
Gloria Shaffer Tannenbaum
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The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin [PDF]
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor [PDF]
Proceedings of the National Academy of Sciences, 2004 Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of tissue extracts in a cell line engineered to overexpress the GHSR led to the identification of a natural agonist called ghrelin.
Yuxiang Sun +3 more
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Adenosine Is an Agonist of the Growth Hormone Secretagogue Receptor [PDF]
Endocrinology, 2000 Growth hormone secretagogues (GHSs) are synthetic compounds that induce GH release in several species, including man. The aim of the current study was to identify hypothalamic GHS receptor (GHS-R) agonists. This led to the discovery of adenosine as a GHS-R agonist.
Søren Tullin
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Growth hormone secretagogue receptor antagonists
Expert opinion on therapeutic patents, 2012 The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
Luca Costantino
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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
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Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor [PDF]
Molecular Metabolism, 2018 Objective: The blood–brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB.
Elizabeth M. Rhea +5 more
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Toward a consensus nomenclature for ghrelin, its non-acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor. [PDF]
J Neuroendocrinol, 2023 Perelló M +4 more
europepmc +3 more sources