The growth hormone secretagogue receptor
Growth Hormone & IGF Research, 1999 The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
KORBONITS M. +3 more
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Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
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Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]
, 2011 The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge +4 more
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Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]
, 2015 BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton +42 more
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Structure and Physiological Actions of Ghrelin
Scientifica, 2013 Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
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Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway
Indian Journal of Animal Sciences, 2016 Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG +6 more
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Dos peptídeos liberadores do hormônio de crescimento (HC) à ghrelina: descoberta de novos moduladores da secreção de HC [PDF]
, 2006 Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues.
Lengyel, Ana Maria Judith
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Ghrelin and the growth hormone secretagogue receptor in growth and development [PDF]
International Journal of Obesity, 2009 The pancreas is a major source of ghrelin in the perinatal period, whereas gastric production progressively increases after birth. Loss of function of the genes for ghrelin or for the constitutively activated growth hormone secretagogue receptor (GHSR) does not affect birth weight and early postnatal growth.
J-P, Chanoine, K, De Waele, P, Walia
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Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.
Megan Herodes +8 more
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Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor
eLife, 2021 There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy.
Maxime Louet +17 more
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