Results 51 to 60 of about 5,406 (173)
A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Advanced Science, 2023 Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood.
Tingting Yi +21 more
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Molecular Metabolism, 2015 Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the ...
T.D. Müller +56 more
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Effect of Ghrelin on the Cardiovascular System
Biology, 2022 Ghrelin, an n-octanoyl-modified 28-amino-acid-peptide, was first discovered in the human and rat stomach as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Ghrelin-GHS-R1a signaling regulates feeding behavior and energy balance,
Hiroshi Hosoda
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How the ghrelin receptor recognizes the acyl-modified orexigenic hormone
Frontiers in Molecular NeuroscienceGhrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura +3 more
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Children, 2021 Astragalus extract mixture HT042 is a standardized functional food granted by the Korean FDA for promoting “Children’s Height Growth”. In this study, we determined whether HT042 affects circulatory Insulin-like growth factor-1 (IGF-1) after ...
Donghun Lee +5 more
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Ghrelin, food intake, and botanical extracts: A Review [PDF]
Avicenna Journal of Phytomedicine, 2015 A kind of growth hormone secretagogue (GHS), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (GHS-R1a) resulting the release of growth hormone (GH).
Peyman Rezaie +2 more
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Recent Advances in Potential Clinical Application of Ghrelin in Obesity
Journal of Obesity, 2012 Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelin O-acyltransferase (GOAT).
Christine Delporte
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Growth Hormone Secretagogue Receptor Expression in Human Pituitary Tumors1 [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1998 The GH secretagogue (GHS) receptor (GHS-R) has been characterized and cloned. It is a member of a family of seven transmembrane receptors and is closely related to the neurotensin and TRH receptors. To determine the expression of this receptor in normal anterior pituitary and in 24 human pituitary adenomas, we analyzed GHS-R messenger ribonucleic acid (
Monica M. Skinner +4 more
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Effect of unacylated ghrelin on peripheral nerve regeneration
European Journal of Histochemistry, 2021 Ghrelin is a circulating peptide hormone released by enteroendocrine cells of the gastrointestinal tract as two forms, acylated and unacylated. Acylated ghrelin (AG) binds to the growth hormone secretagogue receptor 1a (GHSR1a), thus stimulating food ...
Giulia Ronchi +8 more
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Genetics Selection Evolution, 2005 The genes that are part of the somatotropic axis play a crucial role in the regulation of growth and development of chickens. The identification of genetic polymorphisms in these genes will enable the scientist to evaluate the biological relevance of ...
Yang Guanfu +5 more
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