Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect [PDF]
, 2009 [Abstract] The first “growth hormone secretagogues” (GHSs) were discovered by Bowers et al. in 1977. In 1996 the GHSs receptor (GHS-R 1a) was cloned. The endogenous ligand for this receptor, ghrelin, was not identified until 1999.
Cordido, Fernando +3 more
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Dynamin Is Functionally Coupled to Insulin Granule Exocytosis [PDF]
, 2007 The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation.
Gaisano, HY +7 more
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Structure and Physiological Actions of Ghrelin
Scientifica, 2013 Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj +1 more source
Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway
Indian Journal of Animal Sciences, 2016 Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG +6 more
doaj +1 more source
Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues [PDF]
Molecular Endocrinology, 1998 AbstractAntibodies raised against an intracellular and extracellular domain of the GH secretagogue receptor (GHS-R) confirmed that its topological orientation in the lipid bilayer is as predicted for G protein-coupled receptors with seven transmembrane domains.
JR Tata +14 more
openaire +4 more sources
Am J Physiol Regul Integr Comp Physiol, 2018 The hormone ghrelin promotes eating and is widely considered to be a hunger signal. Ghrelin receptors, growth hormone secretagogue receptors (GHSRs), are found in a number of specific regions throughout the brain, including the lateral septum (LS), an ...
Terrill SJ +4 more
europepmc +2 more sources
Dos peptídeos liberadores do hormônio de crescimento (HC) à ghrelina: descoberta de novos moduladores da secreção de HC [PDF]
, 2006 Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues.
Lengyel, Ana Maria Judith
core +4 more sources
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor
eLife, 2021 There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy.
Maxime Louet +17 more
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Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature [PDF]
Journal of Clinical Investigation, 2006 The growth hormone (GH) secretagogue receptor (GHSR) was cloned as the target of a family of synthetic molecules endowed with GH release properties. As shown recently through in vitro means, this receptor displays a constitutive activity whose clinical ...
Jacques Pantel
openalex +2 more sources
Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]
, 2015 BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton +42 more
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