A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration
BMC Veterinary Research, 2012 Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga +6 more
doaj +1 more source
Ghrelin and growth hormone secretagogues (GHS): modulation of growth hormone secretion and therapeutic applications [PDF]
, 2008 Growth hormone-releasing hormone (GHRH) and somatostatin modulate growth hormone (GH) secretion. A third mechanism was discovered in the last decade, involving the action of growth hormone secretagogues (GHS).
Correa-Silva, Silvia R. +2 more
core +2 more sources
Ghrelin receptors in non-mammalian vertebrates
Frontiers in Endocrinology, 2013 The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya +2 more
doaj +1 more source
Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.
Megan Herodes +8 more
doaj +1 more source
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse. [PDF]
J Comp Neurol, 2014 Growth hormone secretagogue receptor (GHSR) 1a is the only molecularly identified receptor for ghrelin, mediating ghrelin‐related effects on eating, body weight, and blood glucose control, among others. The expression pattern of GHSR within the brain has
Mani BK +7 more
europepmc +2 more sources
Biomolecules, 2022 Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be further illuminated, in particular with regard to the structural impact of GPCR C ...
Myriam Guillien +10 more
doaj +1 more source
Ghrelin and lipid metabolism: key partners in energy balance [PDF]
, 2010 Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in "Journal of Molecular Endocrinology", but the version presented here has not yet been copy-edited, formatted or proofed ...
Cordido, Fernando +6 more
core +2 more sources
The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis [PDF]
Endocrinology, 2003 Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-activated receptor gamma 2 (PPAR ...
Choi, Kichoon +8 more
openaire +4 more sources
Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R
Scientific Reports, 2017 Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear.
Geetali Pradhan +7 more
doaj +1 more source
Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain
Frontiers in Endocrinology, 2014 The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern +2 more
doaj +1 more source