The Ghrelin Receptor (Ghsr) Gene Polymorphism in Indonesian Local Chicken and Crossbreed is Associated with Carcass Traits [PDF]
, 2017 Ghrelin receptor (GHSR) gene is candidate gene for growth performance in chicken by modulating growth hormone release from the pituitary by binding to its ligand of ghrelin.
Arief, I. I. (Irma) +4 more
core +2 more sources
Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]
, 2016 The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B. +8 more
core +1 more source
A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration
BMC Veterinary Research, 2012 Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga +6 more
doaj +1 more source
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +1 more source
Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain
Frontiers in Endocrinology, 2014 The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern +2 more
doaj +1 more source
Biomolecules, 2022 Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be further illuminated, in particular with regard to the structural impact of GPCR C ...
Myriam Guillien +10 more
doaj +1 more source
Blockade of the growth hormone (GH) receptor unmasks rapid GH-releasing peptide-6-mediated tissue-specific insulin resistance [PDF]
, 2001 The roles of GH and its receptor (GHR) in metabolic control are not yet fully understood. We studied the roles of GH and the GHR using the GHR antagonist pegvisomant for metabolic control of healthy nonobese men in ...
Bidlingmaier, M. (Martin) +6 more
core +1 more source
Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R
Scientific Reports, 2017 Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear.
Geetali Pradhan +7 more
doaj +1 more source
Ghrelin receptors in non-mammalian vertebrates
Frontiers in Endocrinology, 2013 The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya +2 more
doaj +1 more source
Ghrelin causes hyperphagia and obesity in rats. [PDF]
, 2001 Ghrelin, a circulating growth hormone–releasing pep-tide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghre-lin concentration was compared with ...
Abbott, CR +10 more
core +1 more source