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Growth Hormone Therapy in Adults
Frontiers in Neuroendocrinology, 2001The importance of growth hormone (GH) deficiency in adults became evident 10 to 15 years ago, when the first clinical studies on GH replacement therapy in adults were published. Since then, a number of studies have been reported showing that GH replacement therapy can improve this condition.
Conceicao, F.L. +3 more
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Best Practice & Research Clinical Endocrinology & Metabolism, 2002
Since 1958 growth hormone (GH) has been used as substitution treatment for children with GH deficiency. At present, it is clear that a dose of 0.23 mg/kg/week can lead to a final height close to target height, but in view of the wide inter-individual variation, alternative regimens based on invidualizing the dosage with the help of prediction models ...
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Since 1958 growth hormone (GH) has been used as substitution treatment for children with GH deficiency. At present, it is clear that a dose of 0.23 mg/kg/week can lead to a final height close to target height, but in view of the wide inter-individual variation, alternative regimens based on invidualizing the dosage with the help of prediction models ...
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The Journal of the Association of Physicians of India, 2000
Growth hormone therapy with rhGH (recombinant human growth hormone) has been recommended for treatment of GH deficient short stature in children, repeated hypoglycemias in infancy and early childhood due to GH deficiency, short stature accompanying chronic renal failure prior to renal transplantation and Turner's syndrome.
R J, Dash, R, Muralidharan, V, Talwar
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Growth hormone therapy with rhGH (recombinant human growth hormone) has been recommended for treatment of GH deficient short stature in children, repeated hypoglycemias in infancy and early childhood due to GH deficiency, short stature accompanying chronic renal failure prior to renal transplantation and Turner's syndrome.
R J, Dash, R, Muralidharan, V, Talwar
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Growth Hormone Replacement Therapy
JAMA: The Journal of the American Medical Association, 1966Seven children with anterior hypopituitarism and two children with possible isolated growth-hormone deficiency have been treated with injections of human pituitary growth hormone (HGH) for periods of three months to 3 1/2 years. Administration of HGH was planned to demonstrate the minimal dosage and the maximal interval between injections which are ...
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Growth Hormone Replacement Therapy for Growth Hormone-Deficient Adults
Drugs, 1995Recent research has confirmed previous clinical suspicion that adults with pituitary disease and growth hormone (GH) deficiency have impaired physical and psychological performance even in the presence of adequate adrenal, thyroid and gonadal hormone replacement therapy.
J, Powrie, A, Weissberger, P, Sönksen
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Growth Hormone Therapy in Achondroplasia
Hormone Research in Paediatrics, 2000Achondroplasia is one of the most common causes of severe rhizomelic dwarfism. We have previously reported the growth-promoting effect of growth hormone (GH) in this disorder. In this expanded clinical study, dose dependency and the long-term effect of GH were also investigated.
Y, Seino +8 more
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Growth Hormone Therapy in Progeria
Journal of Pediatric Endocrinology and Metabolism, 2007Catabolic processes seen in Hutchinson-Gilford progeria resemble those of normal aging and, in the affected children, usually result in death at an early age. In addition to its growth promoting effects, growth hormone (GH) has potent anabolic properties. Administration of GH ameliorates some of the catabolic effects of normal aging.
Ab, Sadeghi-Nejad, Laurie, Demmer
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Growth hormone therapy in achondroplasia
American Journal of Medical Genetics, 1992AbstractA pilot study was carried out to examine the safety and efficacy of recombinant human growth hormone for growth‐promoting therapy of achondroplasia. The data suggest that the agent in doses used to treat non‐GH‐deficient forms of short stature (0.3 mg/kg/wk) modestly increases overall height velocity in some children with achondroplasia.
W A, Horton +5 more
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Growth hormone therapy in hypochondroplasia
Acta Paediatrica, 1999Ramaswami U, Hindmarsh PC, Brook CGD. Growth hormone therapy in hypochondroplasia. Acta Pædiatr 1999; Suppl 428: 116–17. Stockholm. ISSN 0803–5326Patients with hypochondroplasia present with variable phenotypes. Children with severe short stature and disproportion of the body segments usually have the mutation Asn540Lys. They respond to growth hormone (
U, Ramaswami, P C, Hindmarsh, C G, Brook
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Growth hormone therapy in achondroplasia
Acta Endocrinologica, 1993The status of growth hormone (GH) secretion together with the effect of GH therapy was studied in six children with achondroplasia. One patient had impaired GH secretion, which may, in part, be due to obesity. The pre-GH-treatment height velocity was 3.8±0.7 cm/year, but this increased to 6.0±1.0 cm/year in the first year of treatment and to 4.4±0.6 cm/
Y, Nishi +4 more
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