Results 51 to 60 of about 2,687 (162)

Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours

ESMO Gastrointestinal Oncology
Background: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs.
M. Berndsen, F. Puls, A. Thornell, Y. Arvidsson, A. Muth, S. Lindskog, E. Elias   +6 more
doaj   +1 more source

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils [PDF]

Proceedings of the National Academy of Sciences, 2011
Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution of infection, yet these cells are involved in perpetuation of different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both ...
Rafael Sanguinetti, Czepielewski, Bárbara Nery, Porto, Lucas Bortolotto, Rizzo, Rafael, Roesler, Ana Lúcia, Abujamra, Larissa Garcia, Pinto, Gilberto, Schwartsmann, Fernando de Queiroz, Cunha, Cristina, Bonorino   +8 more
openaire   +2 more sources

Anisotropy in Dry‐Type Valve‐Side Bushings of Converter Transformer: Phenomena and Effects

High Voltage, Volume 11, Issue 3, Page 859-868, June 2026.
ABSTRACT The safe and stable working of dry‐type valve‐side bushings, important components of converter transformers, is essential. In recent years, poor design has led to several core breakdown, flashover and cracking failures. The bushing cores, composed of crepe paper and aluminium foil, exhibit significant anisotropic physical properties due to its
Gaoyi Shang, Xueyang Bai, Wanhao Shi, Jinzhong Li, Shuqi Zhang, Hao Tang, Xuandong Liu   +6 more
wiley   +1 more source

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Nature Communications, 2022
Gastrin-releasing peptide receptors (GRPR) are involved in pruriceptive behaviours. Here the authors show that neuronal pentraxin 2 upregulated in primary sensory neurons in chronic itch models is required for facilitating excitatory synaptic inputs onto
Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi, Konatsu Asai, Miho Shiratori-Hayashi, Mei-Fang Xiao, Hirotaka Sakamoto, Paul F. Worley, Makoto Tsuda   +9 more
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Advances in the Research of Radioactive Molecular Probes Targeting GRPR

Journal of Isotopes
Gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate cancer，breast cancer，and gastrointestinal tumors，but lowly expressed in normal tissues and organs，providing an ideal target for molecular imaging.
Minyi ZHANG, Xiangyu QIN, Xiaoyu FAN, Baoqi ZHANg, Kai WEN, Xueqin XIANG   +5 more
doaj   +1 more source

Targeting rectal cancer using fluorescent nanoparticles conjugated to a novel GRPR-Binding peptide for tumor imaging applications

Materials & Design
Surgical treatment of rectal cancer is difficult due to anatomical complexity. To improve tumor resection, fluorescence-guided surgery (FGS) has been developed using near-infrared fluorescence (NIRF, approximately 800 nm) and a dedicated camera system ...
Somayeh Rezaei, Mark Fonteyne, Luis J. Cruz, Nada Badr, Ajinkya Manelkar, Mahin Saberi, Ronald L.P. van Vlierberghe, Alexander L. Vahrmeijer, Christina Eich, Fernando Albericio, Louise. van der Weerd, Peter J.K. Kuppen   +11 more
doaj   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 415-422, March 2026.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior

Cell Reports, 2022
Summary: Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival of social animals. Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates ...
Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen   +24 more
doaj   +1 more source

Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. [PDF]

PLoS ONE, 2013
Pruritus (itch) is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e.
Devki D Sukhtankar, Mei-Chuan Ko
doaj   +1 more source