Results 31 to 40 of about 2,687 (162)

Human gastrin- releasing peptide receptor expression in women with uterine cervix cancer

Frontiers in Oncology, 2023
Introduction212Pb-DOTAM-GRPR1 is a pharmaceutical radioimmunoconjugate consisiting of an α-particle-emitting radionuclide lead-212 (212Pb), a metal chelator DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane), and a gastrin ...
Charles A. Kunos, Denise Fabian, Dana Napier, Mark S. Stonecypher, Ravyn M. Duncan, Jason Hurt   +5 more
doaj   +1 more source

Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory. [PDF]

PLoS ONE, 2012
Links between synaptic plasticity in the lateral amygdala (LA) and Pavlovian fear learning are well established. Neuropeptides including gastrin-releasing peptide (GRP) can modulate LA function. GRP increases inhibition in the LA and mice lacking the GRP
Frederique Chaperon, Markus Fendt, Peter H Kelly, Kurt Lingenhoehl, Johannes Mosbacher, Hans-Rudolf Olpe, Peter Schmid, Christine Sturchler, Kevin H McAllister, P Herman van der Putten, Christine E Gee   +10 more
doaj   +1 more source

⁶⁸Ga-Labeled [Thz¹⁴]Bombesin(7–14) Analogs: Promising GRPR-Targeting Agonist PET Tracers with Low Pancreas Uptake

Molecules, 2023
With overexpression in various cancers, the gastrin-releasing peptide receptor (GRPR) is a promising target for cancer imaging and therapy. However, the high pancreas uptake of reported GRPR-targeting radioligands limits their clinical application.
Lei Wang, Ivica Jerolim Bratanovic, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Chengcheng Zhang, Ruiyan Tan, François Bénard, Kuo-Shyan Lin   +9 more
doaj   +1 more source

Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Cell Reports, 2018
Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi, Xian-Yu Liu, Devin M. Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R. Bruchas, Zhou-Feng Chen   +20 more
doaj   +1 more source

100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn

Frontiers in Neuroscience, 2021
BackgroundClinical studies have shown that electroacupuncture (EA) alleviates chronic itch. Gastrin-releasing peptide receptor (GRPR) and dynorphin (DYN) in the spinal dorsal horn positively or negatively regulate itch, respectively.
Hong-Ping Li, Xiao-Yu Wang, Chao Chen, Jing-Jing Li, Chi Yu, Li-Xue Lin, Zi-E Yu, Zhi-Yuan Jin, He Zhu, Hong-Chun Xiang, Xue-Fei Hu, Jie Cao, Xiang-Hong Jing, Man Li   +13 more
doaj   +1 more source

Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer

Pharmaceutics, 2021
Background: Gastrin-releasing peptide receptor (GRPR) is an important target for imaging of prostate cancer. The wide availability of single-photon emission computed tomography/computed tomography (SPECT/CT) and the generator-produced 99mTc can be ...
Ayman Abouzayed, Sara S. Rinne, Hamideh Sabahnoo, Jens Sörensen, Vladimir Chernov, Vladimir Tolmachev, Anna Orlova   +6 more
doaj   +1 more source

Synthesis, Characterization and In Vitro Evaluation of Hybrid Monomeric Peptides Suited for Multimodal Imaging by PET/OI: Extending the Concept of Charge—Cell Binding Correlation

Pharmaceuticals, 2021
In the context of hybrid multimodal imaging agents for gastrin releasing peptide receptor (GRPR) targeting, a correlation between the net charge and the receptor affinity of the agents was recently found.
Marco Maspero, Xia Cheng, Valeska von Kiedrowski, Clelia Dallanoce, Björn Wängler, Ralph Hübner, Carmen Wängler   +6 more
doaj   +1 more source

Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord

Frontiers in Molecular Neuroscience, 2023
The superficial dorsal horn (SDH) of the spinal cord contains a diverse array of neurons. The vast majority of these are interneurons, most of which are glutamatergic. These can be assigned to several populations, one of which is defined by expression of
Raphaëlle Quillet, Maria Gutierrez-Mecinas, Erika Polgár, Allen C. Dickie, Kieran A. Boyle, Masahiko Watanabe, Andrew J. Todd   +6 more
doaj   +1 more source

ProCA1.GRPR: A New Imaging Agent in Cancer Detection [PDF]

Biomarkers in Medicine, 2016
Precision molecular imaging addresses major medical gaps including the early detection of small lesion and biomarker expression, especially for high-risk patients, and monitoring the dynamic changes of biomarkers during disease progression and upon therapeutic treatment.
Fan, Pu, Shenghui, Xue, Jenny J, Yang
openaire   +2 more sources

Prospects of Targeting the Gastrin Releasing Peptide Receptor and Somatostatin Receptor 2 for Nuclear Imaging and Therapy in Metastatic Breast Cancer. [PDF]

PLoS ONE, 2017
The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal candidates for receptor-mediated nuclear imaging and therapy.
Simone U Dalm, Willemijne A M E Schrijver, Anieta M Sieuwerts, Maxime P Look, Angelique C J Ziel-van der Made, Vanja de Weerd, John W Martens, Paul J van Diest, Marion de Jong, Carolien H M van Deurzen   +9 more
doaj   +1 more source