Results 21 to 30 of about 2,687 (162)

NeoBOMB1, a GRPR-Antagonist for Breast Cancer Theragnostics: First Results of a Preclinical Study with [67Ga]NeoBOMB1 in T-47D Cells and Tumor-Bearing Mice

Molecules, 2017
Background: The GRPR-antagonist-based radioligands [67/68Ga/111In/177Lu]NeoBOMB1 have shown excellent theragnostic profiles in preclinical prostate cancer models, while [68Ga]NeoBOMB1 effectively visualized prostate cancer lesions in patients.
Theodosia Maina, Berthold A Nock, Simone Dalm   +2 more
exaly   +3 more sources

A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression [PDF]

EJNMMI Research
Background Gastrin-releasing peptide receptor (GRPR) is overexpressed in several cancers, including prostate and breast, making it an attractive target for radiopharmaceutical development.
Esther Olaniran Håkansson, Ivan V. Zelepukin, Karim Obeid, Athanasios Bitzios, Ekaterina Bezverkhniaia, Amulya Sunkara, Ulrika Rosenström, Anna Orlova, Luke R. Odell, Panagiotis Kanellopoulos   +9 more
doaj   +2 more sources

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

Pharmaceutics, 2019
Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are overexpressed in most prostate cancers. GRPR expression is higher in early stages while PSMA expression increases with progression.
Anna Orlova, Mats Larhed, Bogdan Mitran   +2 more
exaly   +3 more sources

Advances of radiolabeled GRPR ligands for PET/CT imaging of cancers

Cancer Imaging
GRPR is a type of seven-transmembrane G-protein coupled receptor that belongs to the bombesin protein receptor family. It is highly expressed in various cancers, including prostate cancer, breast cancer, lung cancer, gastrointestinal cancer, and so on ...
Yuze Ma, Feng Gao
doaj   +3 more sources

Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system

Frontiers in Molecular Neuroscience, 2023
The prevalence of allergic conjunctivitis in itchy eyes has increased constantly worldwide owing to environmental pollution. Currently, anti-allergic and antihistaminic eye drops are used; however, there are many unknown aspects about the neural circuits
Keiko Takanami, Keiko Takanami, Keiko Takanami, Masaya Kuroiwa, Ren Ishikawa, Yuji Imai, Yuji Imai, Akane Oishi, Akane Oishi, Midori Hashino, Yasushi Shimoda, Hirotaka Sakamoto, Hirotaka Sakamoto, Tsuyoshi Koide, Tsuyoshi Koide   +14 more
doaj   +1 more source

66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26

Scientific Reports, 2021
Molecular imaging of the gastrin-releasing peptide receptor (GRPR) could improve patient management in prostate cancer. This study aimed to produce gallium-66 (T½ = 9.5 h) suitable for radiolabeling, and investigate the imaging properties of gallium-66 ...
Sara S. Rinne, Ayman Abouzayed, Katherine Gagnon, Vladimir Tolmachev, Anna Orlova   +4 more
doaj   +1 more source

GRPR/PI3Kγ: Partners in Central Transmission of Itch [PDF]

The Journal of Neuroscience, 2015
The gastrin-releasing peptide (GRP) and its receptor (GRPR) are important components of itch transmission. Upstream, but not downstream, aspects of GRPR signaling have been investigated extensively. We hypothesize that GRPR signals in part through the PI3Kγ/Akt pathway. We used pharmacological, electrophysiological, and behavioral approaches to further
Paula J.S. Pereira, Gustavo D.B. Machado, Giuliano M. Danesi, Francesca F. Canevese, Vemuri B. Reddy, Talita C.B. Pereira, Maurício R. Bogo, Yung-Chih Cheng, Cedric Laedermann, Sébastien Talbot, Ethan A. Lerner, Maria M. Campos   +11 more
openaire   +2 more sources

Gastrin-Releasing Peptide Receptor in Low Grade Prostate Cancer: Can It Be a Better Predictor Than Prostate-Specific Membrane Antigen?

Frontiers in Oncology, 2021
The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on the bases of tissue expression of gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA).
Pinuccia Faviana, Laura Boldrini, Paola Anna Erba, Iosè Di Stefano, Francesca Manassero, Riccardo Bartoletti, Luca Galli, Carlo Gentile, Massimo Bardi   +8 more
doaj   +1 more source

GRP Receptor Regulates Depression Behavior via Interaction With 5-HT2a Receptor

Frontiers in Psychiatry, 2020
ObjectiveAccumulating evidences indicate that gastrin-releasing peptide receptor (GRPR) may contribute to the pathophysiology of depression. However, the mechanism of the involvement of GRPR in the progression of depression remains unclear.
Dan Xiang, Huiling Wang, Siqi Sun, Lihua Yao, Ruiting Li, Xiaofen Zong, Gaohua Wang, Zhongchun Liu   +7 more
doaj   +1 more source

Critical role of GRP receptor–expressing neurons in the spinal transmission of imiquimod‐induced psoriatic itch

Neuropsychopharmacology Reports, 2020
Aim Ample evidence indicates that gastrin‐releasing peptide receptor (GRPR)–expressing neurons play a critical role in the transmission of acute itch. However, the pathophysiology of spinal mechanisms underlying intractable itch such as psoriasis remains
Norikazu Kiguchi, Fumihiro Saika, Yohji Fukazawa, Shinsuke Matsuzaki, Shiroh Kishioka   +4 more
doaj   +1 more source