Results 11 to 20 of about 2,687 (162)

GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma

Cells
Metastasis is a leading cause of lung adenocarcinoma (LUAD)-related mortality and presents significant challenges for treatment. The gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor (GPCR) family, has an unclear role ...
Dong-Gun Kim
exaly   +3 more sources

Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation [PDF]

Nature Communications
Neuropeptides are the largest class of neuromodulators. It has been shown that subpopulations of ventral tegmental area (VTA) dopamine neurons express mRNA for the neuropeptide Gastrin-releasing peptide (GRP); however, its functional relevance in ...
Erin E. Aisenberg, Thomas L. Li, Hongli Wang, Atehsa A. Sahagun, Emilie M. Tu, Helen S. Bateup   +5 more
doaj   +2 more sources

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Pharmaceutics, 2020
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are promising targets for molecular imaging of prostate cancer (PCa) lesions.
Anna Orlova, Mats Larhed, Bogdan Mitran   +2 more
exaly   +3 more sources

Gastrin-releasing peptide receptor (GRPR) as a novel biomarker and therapeutic target in prostate cancer

Annals of Medicine
Aim: This comprehensive review aims to explore the potential applications of Gastrin-releasing peptide receptor (GRPR) in the diagnosis and treatment of prostate cancer.
Yi Cai
exaly   +3 more sources

Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Targeting the gastrin-releasing peptide receptor (GRPR) is a promising approach for radionuclide therapy in prostate and breast cancers.
Karim Obeid, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova, Panagiotis Kanellopoulos   +4 more
doaj   +2 more sources

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Gastrin-releasing peptide receptor (GRPR) attracts increasing attention as a target for radiotheranostic applications. We previously developed a metabolically stable GRPR-targeting peptide, incorporating α-methyl-L-tryptophan within its ...
Karim Obeid, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova, Panagiotis Kanellopoulos   +4 more
doaj   +2 more sources

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy. [PDF]

Precis Radiat Oncol
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chen C, Yang M, Wang J, Zhang L, Huang S, Xu X, Liu Y.   +6 more
europepmc   +2 more sources

GRPR-induced FAM135A expression promote perineural invasion in prostate cancer. [PDF]

Mol Cancer
Perineural invasion (PNI) is an independent adverse prognostic marker for prostate cancer (PCa) metastasis. Gastrin releasing peptide receptor (GRPR) targeted imaging and therapeutics have entered clinical trials, while its role in PCa perineural invasion remains unclear.
Zhang N, Ruan X, Chen S, Shi R, Yang X, Zhan Y, Chun S, Yao C, Ali S, Ho BS, Ng AT, Lo RK, Na R.   +12 more
europepmc   +3 more sources

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review. [PDF]

Int J Dermatol
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Akiska YM, Gandhi I, Adler R, Fayyad D, Bhagchandani P, Afzal S, Adawi W, Patel S, Kwatra SG.   +8 more
europepmc   +2 more sources

Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective: This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity.
Martina Lichtenfels, Rafaella Almeida Lima Nunes, Rossana Veronica Mendoza López, Camila Alves da Silva, Luiz Carlos Zeferino, Vanesca de Souza Lino, Adhemar Longatto-Filho, Louise De Brot, Silvia Helena Rabelo-Santos, Daniela Baumann Cornelio, Enrique Boccardo, Caroline Brunetto de Farias, Lara Termini   +12 more
doaj   +2 more sources