Results 31 to 40 of about 18,138 (288)

Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Mediators of Inflammation, 2022
The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of the NLRP3 inflammasome cleaves gasdermin D (GSDMD) and induces pyroptosis, a ...
Eun Bi Ma, Hafiz Muhammad Ahmad Javaid, Do-Hyeon Jung, Jong-Hwan Park, Joo Young Huh   +4 more
doaj   +1 more source

Development of diagnostic and prognostic biomarker models for knee osteoarthritis based on NLRP3 inflammasome activation [PDF]

Journal of Medical Biochemistry
Background: This study aimed to characterize the expression profiles of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream effectors [Interleukin (IL)-1b, IL-18, and Gasdermin-D (GSDMD)] in degenerative knee ...
Xiong Shui, Zhou Junxin, Dong Yuying, Long Ling, Deng Gaorong   +4 more
doaj   +1 more source

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease

Journal of Inflammation Research, 2021
Jing Zhang,* Yiqin Dai,* Yujing Yang, Jianjiang Xu Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Shanghai Key Laboratory of Visual Impairment and Restoration; NHC Key Laboratory of Myopia, Fudan University ...
Zhang J, Dai Y, Yang Y, Xu J
doaj  

Gasdermin D protects against Streptococcus equi subsp. zooepidemicus infection through macrophage pyroptosis

Frontiers in Immunology, 2022
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus, SEZ) is an essential zoonotic bacterial pathogen that can cause various inflammation, such as meningitis, endocarditis, and pneumonia. Gasdermin D (GSDMD) is involved in cytokine release and cell
Guobin Xu, Zheng Guo, Yuxuan Liu, Yalin Yang, Yongjin Lin, Chunliu Li, Yunfei Huang, Yunfei Huang, Qiang Fu, Qiang Fu   +9 more
doaj   +1 more source

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Journal of Inflammation Research, 2021
Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J   +7 more
doaj  

Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis

Journal of Inflammation Research, 2021
Ding Wang,1,* Xi Zhan,1,* Rui Wu,2 Yan You,3 Weixian Chen,1 Liang Duan1 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Laboratory Medicine,
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L   +5 more
doaj  

Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS

Ecotoxicology and Environmental Safety, 2023
Aim: We investigate the mechanism whereby chlorpyrifos (CHI), an environmental toxin, causes liver injury by inducing ferroptosis in hepatocytes. Methods: The toxic dose (LD50 = 50 μM) of CHI for inducing AML12 injury in normal mouse hepatocytes was ...
Chenyang Han, Jian Sheng, Hongyan Pei, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Chenxi Cao, Yi Yang   +8 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Ion Man: GSDMD Punches Pores to Knock Out cGAS [PDF]

Immunity, 2018
The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection.
Rebecca, Feltham, James E, Vince
openaire   +2 more sources