The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
eLifeCaspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME).
Hang Xu +4 more
doaj +1 more source
A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma [PDF]
Malignant melanoma ranks among the most aggressive forms of cancer, with high rates of metastasis and recurrence, as well as a poor prognosis. Consequently, an urgent need is to develop novel precision therapeutic strategies and corresponding drugs ...
Dong, Xinyue +6 more
core +1 more source
Cell Death and DiseaseDiabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology.
Hongkun Zhao +4 more
doaj +1 more source
Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies
Sensory Neuroscience, Volume 2, Issue 1, March 2026.ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao +6 more
wiley +1 more source
Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection. [PDF]
Monocytes are actively recruited to sites of infection and produce the potent proinflammatory cytokine IL-1β. We previously showed that IL-1β release during Toxoplasma gondii infection of primary human monocytes requires the NLRP3 inflammasome and ...
Batarseh, Sarah N +7 more
core +1 more source
PRECLINICAL EVALUATION OF IMMUNOMODULATORY EFFECTS OF AURORA KINASE INHIBITION IN HUMAN PAPILLOMAVIRUS POSITIVE CANCERS [PDF]
, 2023 Human papillomavirus (HPV) is the causative agent of cervical cancer and some cancers of the penis, vulva, vagina, anus, and oropharynx. Current therapies for these cancers include a combination of surgery, radiotherapy, and chemotherapy that often ...
Sinha, Pragya
core +1 more source
The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin
BiomedicinesBackground: Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its ...
Wenyang Lei +5 more
doaj +1 more source
Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release [PDF]
Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the
Bracey, Syrena +12 more
core +1 more source
NLRP1 and gasdermins regulate IL-1β release in human lung fibroblasts infected with respiratory syncytial virus [PDF]
Respiratorisk syncytialvirus (RSV) er en hovedårsak til akutte infeksjoner i luftveiene, spesielt hos spedbarn og eldre. Det inflammatoriske cytokinet interleukin-1β (IL-1β) har vist seg å spille en kritisk rolle i balansen mellom virusindusert celledød ...
Veronika, Tiszlavicz
core
Assessing the role of JNK in human endothelial cell death induced by anti-cancer therapies [PDF]
Cardiovascular disease is a common side effect of cancer treatment, particularly in those who have been disease-free for over 10 years. Several studies have shown that radiation and chemotherapeutics, such as Doxorubicin and Cisplatin, can induce ...
McCulloch, Ashley
core +2 more sources