Results 101 to 110 of about 6,248 (265)

One Novel BiP/GRP78 Inhibitor YUM70 Induces GSDME Dependent Pyroptosis and Enhances Sensitivity To EGFR Inhibitors in cholangiocarcinoma and hepatocellular carcinoma [PDF]

, 2022
Lei Sun, Yanan Liu, Hao Zhou, Mingyan Zhang, Xuelei Cao, Jian Zhang   +5 more
openalex   +1 more source

MnCl2 Nanosheet‐Triggered Mn2+ Storm Enhances Tumor Immunotherapy Through PANoptosis Induction and cGAS‐STING Activation

Aggregate, Volume 7, Issue 1, January 2026.
This study constructs an ultrasound‐assisted liquid‐phase exfoliated MnCl2 nanosheet system for tumor treatment, establishing an immunotherapy strategy combining PANoptosis induction with cGAS‐STING activation. This treatment system does not require the introduction of additional drugs or energy input, enabling multiple combination therapeutic effects ...
Guanglei Ma, Di Li, Yi Chang, Fangli Gao, Qingcong Wei, Xiaofang Shi, Yuming Guo, Zhiguo Hu, Ping'an Ma, Xiaoming Ma   +9 more
wiley   +1 more source

Figure S1 from Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death [PDF]

, 2023
Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei‐Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma, Guanglei Zhuang   +11 more
openalex   +1 more source

Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation

Nature Communications
Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun, Xiao-Dong Jiao, Zhi-Gang Chen, Qi Cao, Jia-Hui Zhu, Qi-Rui Shen, Yi Liu, Zhen Zhang, Fang-Fang Xu, Yu Shi, Jie Tong, Shen-Xi Ouyang, Jiang-Tao Fu, Yi Zhao, Jun Ren, Dong-Jie Li, Fu-Ming Shen, Pei Wang   +17 more
doaj   +1 more source

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Cell Death and Disease
Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli, Rebecca L. Ambrose, Christopher M. Harpur, Maggie Lam, Christopher Hodges, Kristian T. Barry, Alison C. West, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate   +9 more
doaj   +1 more source

Lymph Node‐Targeted Nanomaterials for Controlled Nano‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
This study primarily investigates lymph node‐targeted immunotherapeutic strategies, focusing on the mechanisms of immune response regulation within lymph nodes. By targeting distinct immune signaling pathways, we systematically explore the development of nanodrug delivery systems specifically designed for lymph node targeting to achieve enhanced ...
Yitong Zhao, Mengjun Wang, Ming Ma, Yu Zhang, Haoan Wu   +4 more
wiley   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, Volume 59, Issue 1, January 2026.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma [PDF]

Malignant melanoma ranks among the most aggressive forms of cancer, with high rates of metastasis and recurrence, as well as a poor prognosis. Consequently, an urgent need is to develop novel precision therapeutic strategies and corresponding drugs ...
Dong, Xinyue, Fang, Ruiqin, Li, Xiangmei, Wang, Wei Jia, Wang, Yuan, Yuan, Haokun, Zhang, Ran   +6 more
core   +1 more source

Progress of Programmed Cell Death in Steroid‐Induced Osteonecrosis of the Femoral Head

Orthopaedic Surgery, Volume 18, Issue 1, Page 16-30, January 2026.
Steroid‐induced osteonecrosis of the femoral head is a severe osteoarticular condition resulting from glucocorticoid overuse, characterized by femoral head bone structure collapse and cell death, now predominant among nontraumatic femoral head necroses.
Zhi Kong, Chao Han
wiley   +1 more source

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

eLife
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME).
Hang Xu, Zihao Yuan, Kunpeng Qin, Shuai Jiang, Li Sun   +4 more
doaj   +1 more source