Results 171 to 180 of about 5,144 (202)

Full-length GSDME mediates pyroptosis independent from cleavage

Nature Cell Biology
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates nuclear PARP1, leading to extensive formation of ...
Hang-Zi Chen, Qiao Wu
exaly   +3 more sources

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

Biochemical and Biophysical Research Communications, 2018
Gastric cancer is a malignancy that starts from the cells in the stomach with relatively low overall survival rate. Chemotherapy following resection surgery has been recommended as a curative strategy for gastric cancer. However, the mechanism of the chemotherapy drugs on gastric cancer is not completely understood.
Yubin, Wang, Bo, Yin, Dinuo, Li, Guijun, Wang, Xiangdong, Han, Xuejun, Sun   +5 more
openaire   +2 more sources

Gsdme Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils

Blood, 2023
Introduction Neutrophil extracellular traps (NETs) neutralize bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4), is synonymous with NETosis and is considered independent of ...
Yanfang Peipei Zhu, Mary Helen Speir, ZheHao G Tan, Harold M Hoffman, Lai Ping Wong, Ruslan Sadreyev, Kate L Jeffrey, Ben A Croker   +7 more
openaire   +1 more source

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Acta Pharmacologica Sinica, 2023
Proteasomes are overexpressed in multiple myeloma (MM) and proteasomal inhibitors (PIs) have been widely used for the treatment of MM. PIs are reported to induce MM cell apoptosis but impair necroptosis. In the present study, we found that PIs MG132 and bortezomib induce MM cell pyroptosis, a novel type of cell death, in a GSDME-dependent manner.
Jing-Pei, Liang, Yuan-Ming, He, Yao-Li, Cui, Yue-Ning, Sun, Gui-Song, He, Zhi-Gang, Zhu, Xin-Liang, Mao   +6 more
exaly   +3 more sources

GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer

Journal of Dental Research, 2022
Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered to be linked to antitumor immunity in recent years. However, the role of GSDME in oral squamous cell carcinoma (OSCC) remains to be elucidated. Here, by using a human OSCC tissue microarray, human OSCC tissue, and Tgfbr1/ Pten conditional knockout mice, we found ...
S, Wang, M J, Zhang, Z Z, Wu, S W, Zhu, S C, Wan, B X, Zhang, Q C, Yang, Y, Xiao, L, Chen, Z J, Sun   +9 more
openaire   +2 more sources

Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis

Journal of Dermatological Science, 2021
Oncostatin M (OSM), an interleukin-6 (IL-6) family proinflammatory cytokine, plays a critical role in inflammatory skin diseases, but its mechanism of action is not well understood.To demonstrate the mechanism of OSM induced pyropotosis in normal human epidermal keratinocytes (NHEKs) and immortalized human keratinocytes (HaCaT cells).NHEKs and HaCaT ...
Jun, Liu, Yadan, Zhong, Huiting, Liu, Huan, Yang, Ping, Lu, Yanqiang, Shi, Xuan, Wang, Wen, Zheng, Xiaoling, Yu, Yingping, Xu, Bin, Yang   +10 more
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Cisplatin promotes pyroptosis of gastric cancer cells by activating GSDME

2023
ABSTRACTAccording to studies, numerous chemotherapeutic drugs can facilitate programmed cell death via pyroptosis. Clarifying the mechanism by which cisplatin kills gastric cancer cells is crucial for enhancing gastric cancer’s sensitivity to chemotherapy and elucidating the mechanism of drug resistance in gastric cancer.
Xianglai Jiang, Yongfeng Wang, Chenyu Wang, Haizhong Ma, Miao Yu, Hui Cai   +5 more
openaire   +1 more source

Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis

Hypertension
BACKGROUND: Pulmonary hypertension (PH) is a fatal progressive disease characterized by pulmonary endothelial injury and occlusive pulmonary vascular remodeling. Lysosomal protease cathepsin L degrades essential molecules to participate in the human pathophysiological process. BMPR2 (bone morphogenetic protein type II receptor)
Zhouyangfan Peng, Xue-Yang Luo, Xinyi Li, Yapei Li, Yusi Wu, Yuyang Tian, Bingjie Pan, Aleksandar Petrovic, Djuro Kosanovic, Ralph Theo Schermuly, Clemens Ruppert, Andreas Günther, Zhen Zhang, Chengfeng Qiu, Ying Li, Jun Pu, Xiaohui Li, Alex F. Chen   +17 more
openaire   +2 more sources

[Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor ...
Liting, Peng, Xi, Wang, Weiqian, Wang, Jincao, Xu, Xue, Gao   +4 more
openaire   +1 more source

Streptococcus anginosus promotes gastric cancer progression via GSDME-mediated pyroptosis pathway: Molecular mechanisms of action of GSDME, cleaved caspase-3, and NLRP3 proteins

International Journal of Biological Macromolecules
Streptococcus vasculosus is a common oral and intestinal symbiotic bacteria, but it can transform into a pathogen under certain conditions, affecting the host's immune response. Studies have shown that Streptococcus vasculosus may promote tumor growth and metastasis by activating host inflammatory responses.
Zeshen, Wang, Ruishu, Mou, Shiyang, Jin, Qiancheng, Wang, Yuming, Ju, Pengcheng, Sun, Rui, Xie, Kuan, Wang   +7 more
openaire   +2 more sources