Results 41 to 50 of about 269,348 (283)

Pathway of human AS3MT arsenic methylation [PDF]

, 2014
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was expressed, and the purified enzyme was characterized.
Dheeman, Dharmendra S., Packianathan, Charles, Pillai, Jitesh K., Rosen, Barry P.   +3 more
core   +2 more sources

PROTOCOLO DE HEMORRAGIA OBSTÉTRICA NO PROGRAMA DE BONS PRINCÍPIOS DE PRÁTICAS MÉDICAS (PBM)

Hematology, Transfusion and Cell Therapy
Introdução e objetivo: A hemorragia obstétrica é uma das principais causas de mortalidade materna, exigindo uma abordagem eficaz e padronizada para sua prevenção e tratamento.
RCB Soares, AA Magagna, KJD Olio, NV Almeida, KCG Alves, AHV Almeida, JED Giacomo, JAD Santos, LPS Fontenele, FCV Perini, EB Souza, RA Bento, DE Rossetto   +12 more
doaj   +1 more source

Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates [PDF]

, 2009
In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates (2-S-GSH-DA-o-quinone and 5-S-GSH-DA-o-quinone).
Tit Meng Lim, Zhidong Zhou
core   +1 more source

Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets [PDF]

, 2017
Background: In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing.
Casteleyn, Christophe, De Smet, Stefaan, Degroote, Jeroen, Fransen, Erik, Michiels, Joris, Prims, Sara, Van Cruchten, Steven, Van Ginneken, Chris, Vergauwen, Hans, Wang, Wei   +9 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Extracellular cysteine in connexins: Role as redox sensors [PDF]

, 2016
Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D., Del Rio, R., García, I.E., González, C., Pinto, B.I., Pupo, A., Retamal, M.A., Stehberg, J.   +7 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

PREVALÊNCIA DE SOROLOGIA POSITIVA PARA SÍFILIS DOS DOADORES DO BANCO DE SANGUE SÃO PAULO NO ANO 2022

Hematology, Transfusion and Cell Therapy, 2023
Objetivo: A sífilis é uma doença infecciosa, que tem como agente etiológico o Treponema pallidum e é problema de saúde pública global, que gera preocupação, pois além de ser uma doença sexualmente transmissível, também pode ser transmitida por transfusão
JAD Santos, APC Sessin, JED Giacomo, RA Bento, DE Rossetto, APC Rodrigues   +5 more
doaj   +1 more source

Interaction of ROS and RNS with GSH and GSH/GPX Systems

The FASEB Journal, 2015
Rapid reactivity amongst the free radicals and its capability to inflict severe damages to cell has evolved cell redox systems with multiple pathways of counteracting and counterbalancing mechanisms. One of the important cell redox pathways is glutathione (GSH) and GSH/glutathione peroxidase (GPX) enzyme system.
Juan Chen, Bhagyesh Bhandar, Mahendra Kavdia   +2 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source