Results 51 to 60 of about 360,657 (334)

Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells

Nanotheranostics, 2021
Smart drug delivery systems are required for the site-specific drug targeting to enhance the therapeutic efficiency of a drug. Resveratrol (RV) is a polyphenolic compound with anti-cancer activity. However, its poor aqueous solubility and non-selectivity
Marco Palminteri, N. Dhakar, Alessandra Ferraresi, F. Caldera, Chiara Vidoni, F. Trotta, C. Isidoro   +6 more
semanticscholar   +1 more source

DESAFIOS NO TRANSPORTE E INSTALAÇÃO DE UM IRRADIADOR DE SANGUE

Hematology, Transfusion and Cell Therapy
Objetivos: Apresentar os desafios associados ao transporte e à instalação de um equipamento de 1,8 toneladas, utilizado para a irradiação de sangue por meio de uma fonte de césio-137.
P Fausto, F Seara, D Vieira, M Martins, B Lopes, B Silva, E Ferro   +6 more
doaj   +1 more source

AVALIAÇÃO DO PERFIL EPIDEMIOLÓGICO DE PACIENTES INTERNADOS EM SETOR DE TERAPIA INTENSIVA SUBMETIDOS À TRANSFUSÃO DE HEMOCOMPONENTES

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A medicina transfusional é uma especialidade multidisciplinar responsável pela seleção e utilização adequada dos componentes do sangue. A solicitação de uma transfusão é considerada a partir da avaliação de parâmetros clínicos e laboratoriais,
TOSB Marchesi, MCC Uebele, DSF Costa, MP Machado, JAD Santos, JED Giacomo, I Schettert   +6 more
doaj   +1 more source

Extracellular cysteine in connexins: Role as redox sensors [PDF]

, 2016
Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D., Del Rio, R., García, I.E., González, C., Pinto, B.I., Pupo, A., Retamal, M.A., Stehberg, J.   +7 more
core   +2 more sources

ESTUDO DE DOADORES COM TESTE DE ÁCIDO NUCLEICO ALTERADO PARA HEPATITE B, C E HIV E CORRELAÇÃO COM SOROLOGIA

Hematology, Transfusion and Cell Therapy, 2023
Introdução: Uma das maiores preocupações relacionadas à segurança transfusional é a possibilidade de transmissão de doenças através do sangue transfundido, entre as quais se encontram as hepatites B, C e o HIV.
APC Rodrigues, RA Bento, DE Rossetto, JAD Santos, ACA Pitol, AP Sessin, FJ Benatti, SMC Lira, NJ Moitinho, CLA Rocha, EC Ferreira   +10 more
doaj   +1 more source

Rapid Reaction, Slow Dissociation Aggregation, and Synergetic Multicolor Emission for Imaging the Restriction and Regulation of Biosynthesis of Cys and GSH.

Journal of the American Chemical Society, 2020
Biosynthesis is a necessary process to maintain life. In recent years, research has fully shown that three kinds of biothiols (Cys, Hcy, GSH) mainly play the role in oxidative stress and maintaining cell homeostasis in cells, and that abnormal ...
Huming Yan, Fangjun Huo, Yongkang Yue, Jianbin Chao, C. Yin   +4 more
semanticscholar   +1 more source

PROTOCOLO DE HEMORRAGIA OBSTÉTRICA NO PROGRAMA DE BONS PRINCÍPIOS DE PRÁTICAS MÉDICAS (PBM)

Hematology, Transfusion and Cell Therapy
Introdução e objetivo: A hemorragia obstétrica é uma das principais causas de mortalidade materna, exigindo uma abordagem eficaz e padronizada para sua prevenção e tratamento.
RCB Soares, AA Magagna, KJD Olio, NV Almeida, KCG Alves, AHV Almeida, JED Giacomo, JAD Santos, LPS Fontenele, FCV Perini, EB Souza, RA Bento, DE Rossetto   +12 more
doaj   +1 more source

Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates [PDF]

, 2009
In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates (2-S-GSH-DA-o-quinone and 5-S-GSH-DA-o-quinone).
Tit Meng Lim, Zhidong Zhou
core   +1 more source

Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis

Theranostics, 2020
Background: Glutathione (GSH), the primary antioxidant in cells, could fight against oxidative stress. Tumor cells display a higher GSH level than normal cells for coping with the hyperoxidative state, which meets the requirements of enhanced metabolism ...
Hongxia Tang, Chaoqun Li, Yue Zhang, Hongyue Zheng, Ying Cheng, Jingjing Zhu, Xiaojie Chen, Zhihong Zhu, Ji-Gang Piao, Fanzhu Li   +9 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source