Results 71 to 80 of about 269,348 (283)

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]

, 2017
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto, Benvenuto, Monica, Bergante, Sonia, Giganti, Maria Gabriella, Manzari, Vittorio, Masuelli, Laura, Mattera, Rosanna, Modesti, Andrea, Pluchinotta, Francesca Romana, Tettamanti, Guido, Tresoldi, Ilaria   +10 more
core   +2 more sources

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

PERFIL DE DOADORES COM SOROLOGIA POSITIVA PARA CHAGAS DOS DOADORES DE SANGUE DO GRUPO GSH NO ANO 2022

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: A Doença de Chagas (DC), é causada pelo protozoário Trypanosoma cruzi (T.cruzi) , que é transmitido pela picada ou deposição de fezes de vetores contaminados (barbeiros), sobre os tecidos cutâneos e mucosas do indivíduo.
JAD Santos, APC Sessin, JED Giacomo, RA Bento, DE Rossetto, APC Rodrigues   +5 more
doaj   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

IMPACTO DA TRANSFUSÃO DE TROCA AUTOMATIZADA EM PACIENTE COM DOENÇA FALCIFORME DE EVOLUÇÃO GRAVE CURSANDO COM HEMATOPOIESE EXTRAMEDULAR– RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Resumo: Relato de caso de paciente de 15 anos com Doença Falciforme (DF)de evolução grave, com surgimento de lesão paravertebral evidenciada em exame de ressonância nuclear magnética (RNM), sugerindo hematopoiese extramedular (HEM) e que obteve resolução
PG Moura, VLR Pessoa, BL Raposo, MS Simão, LA Nunes, C Rebello, IG Claudio, RL Lima, L Avelar, F Akil   +9 more
doaj   +1 more source

GSH23.0-0.7+117, a neutral hydrogen shell in the inner Galaxy

, 2004
GSH23.0-0.7+117 is a well-defined neutral hydrogen shell discovered in the VLA Galactic Plane Survey (VGPS). Only the blueshifted side of the shell was detected. The expansion velocity and systemic velocity were determined through the systematic behavior
A. R. Taylor, Cornwell T. J., Dennison B., Garcia-Segura G., Higgs L. A., J. M. Dickey, J. M. Stil, McClure-Griffiths N. M., N. M. McClure‐Griffiths, P. G. Martin, Reich P., Reich W., Royczka M., T. A. Rothwell, Van der Werf P. P.   +14 more
core   +2 more sources

Acute toxicity of arsenic and oxidative stress responses in the embryonic development of the common South American toad Rhinella arenarum [PDF]

, 2015
Arsenic (As), a natural element of ecological relevance, is found in natural water sources throughout Argentina in concentrations between 0.01mg/L and 15mg/L. The autochthonous toad Rhinella arenarum was selected to study the acute toxicity of As and the
Adams, Bagnyukova, Beers, Bongiovanni, Brix, Brodeur, Bundschuh, Chen, Del Conte, Ellman, Evelson, Farnfield, Ferrari, Ferrari, Ferrari, Guidi, Habig, Kensler, Kobayashi, Kono, Lascano, Lascano, Lowry, Lu, Miller, Montagna, Moriarty, Rahman, Rankin, Rizzo, Soria, Sotomayor, Suhendrayatna, Ventura-Lima, Ventura-Lima, Venturino, Venturino, White   +37 more
core   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Ozone Oxidizes Glutathione to a Sulfonic Acid [PDF]

, 2009
Biosurfaces are universally covered with fluid microfilms containing reduced glutathione (GSH) and other antioxidants whose putative roles include the detoxification of ambient ozone (O_3).
Colussi, A. J., Enami, Shinichi, Hoffmann, M. R.   +2 more
core   +1 more source