Results 11 to 20 of about 35,497 (235)
Memory formation in old age requires GSK-3β
Aging Brain, 2021 Glycogen synthase kinase 3β (GSK-3β) is a therapeutic target for various age-related neurodegenerative diseases. It is linked to the two main pathological features of Alzheimer’s disease (AD), tau and amyloid β (Aβ); GSK-3β is a major candidate to ...
Riki Koike +3 more
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Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
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Silencing I2PP2A Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice [PDF]
Frontiers in Aging Neuroscience, 2014 Increase of inhibitor-2 of protein phosphatase-2A (I2PP2A) is associated with PP2A inhibition and tau hyperphosphorylation in Alzheimer’s disease (AD). Down-regulating I2PP2A attenuated amyloidogenesis and improved the cognitive functions in transgenic mice expressing amyloid precursor protein (tg2576).
Yao eZhang +13 more
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Current Oncology, 2023 Advanced bladder cancer (BC) (local invasive and/or metastatic) is not curable even with cytotoxic chemotherapy, immune checkpoint inhibitors, and targeted treatment. Targeting GSK-3β is a promising novel approach in advanced BC.
Yuko Shirono +7 more
doaj +1 more source
Cells, 2020 Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure. Thus, there is an urgent need to understand the molecular mechanism of obesity-associated cardiac dysfunction.
Manisha Gupte +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2009 Glycogen synthase kinase-3β (GSK-3β) is a constitutively active kinase. Since its activation results in neurofibrillary tangle (NFT) deposits in aged and Alzheimer’s disease (AD) brains, GSK-3β may be inhibited under normal conditions but activated under
Akihiko Takashima
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GSK-3β inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer
Diagnostic Pathology, 2018 Background Radiotherapy is one of the most common and effective treatment methods for cancer, and improving the radiosensitivity of tumor tissues during the treatment process is vital.
Jialin Ren +6 more
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Inhibition of glycogen synthase kinase-3β attenuates glucocorticoid-induced suppression of myogenic differentiation in vitro. [PDF]
PLoS ONE, 2014 Glucocorticoids are the only therapy that has been demonstrated to alter the progress of Duchenne muscular dystrophy (DMD), the most common muscular dystrophy in children.
Zhenyu Ma +4 more
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Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between ...
Stephen L. Abrams +16 more
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GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. [PDF]
PLoS ONE, 2016 Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways.
Javier Duran +9 more
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