Results 41 to 50 of about 33,158 (224)

Additional file 2: of The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

, 2018
Table S2. Primers and vshRNAs/siRNAs used in the study. (DOCX 14 kb)
Qiu, Wen-Ze, Zhang, Hai-Bo, Xia, Wei-Xiong, Ke, Liang-Ru, Yang, Jing, Yu, Ya-Hui, Liang, Hu, Huang, Xin-Jun, Liu, Guo-Ying, Li, Wang-Zhong, Xiang, Yan-Qun, Kang, Tie-Bang, Guo, Xiang, Lv, Xing   +13 more
openaire   +1 more source

Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways

Frontiers in Endocrinology, 2014
Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular ...
Colleen M Bartman, Jennifer eEgelston, Sravya eKattula, Leigh C Zeidner, Anthony eD'Ippolito, Bradley W Doble, Christopher J Phiel   +6 more
doaj   +1 more source

Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4⁺ T Lymphocytes

Cells, 2020
Cytokines are the major immune regulators secreted from activated CD4+ T lymphocytes that activate adaptive immunity to eradicate nonself cells, including pathogens, tumors, and allografts.
Cheng-Chieh Tsai, Chin-Kun Tsai, Po-Chun Tseng, Chiou-Feng Lin, Chia-Ling Chen   +4 more
doaj   +1 more source

Molecular docking study of xylogranatins binding to glycogen synthase kinase-3β

Digital Chinese Medicine, 2022
Objective: The mangrove tree Xylocarpus granatum J. Koenig (X. granatum) is a medicinal plant used to treat various diseases in several Asian countries.
Christian Bailly, Gérard Vergoten
doaj   +1 more source

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury

Journal of Pharmacological Sciences, 2009
Although reperfusion is required to salvage ischemic myocardium from necrosis, reperfusion per se induces myocardial necrosis. In this “lethal reperfusion injury”, opening of the mitochondrial permeability transition pore (mPTP) upon reperfusion is ...
Tetsuji Miura, Masahiro Nishihara, Takayuki Miki   +2 more
doaj   +1 more source

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord

Basic and Clinical Neuroscience, 2020
Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-
Mina Rashvand, Samira Danyali, Homa Manaheji   +2 more
doaj  

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Neural Plasticity, 2019
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity.
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Glycogen Synthase Kinase-3 Beta Expression Correlates With Worse Overall Survival in Non-Small Cell Lung Cancer—A Clinicopathological Series

Frontiers in Oncology, 2021
BackgroundGlycogen Synthase Kinase-3 beta (GSK-3β) regulates diverse cell functions including metabolic activity, signaling and structural proteins. GSK-3β phosphorylates target pro-oncogenes and regulates programmed cell death-ligand 1 (PD-L1).
Marclesson Alves, Daniela de Paula Borges, Aline Kimberly, Aline Kimberly, Francisco Martins Neto, Ana Claudia Oliveira, Juliana Cordeiro de Sousa, Juliana Cordeiro de Sousa, Cleto D. Nogueira, Cleto D. Nogueira, Benedito A. Carneiro, Fabio Tavora, Fabio Tavora, Fabio Tavora   +13 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source