Results 31 to 40 of about 33,158 (224)

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

iScience, 2021
Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer ...
Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla   +15 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection

Mediators of Inflammation, 2013
Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3β (GSK-3β) is known to regulate inflammatory response in infectious diseases ...
Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin   +6 more
doaj   +1 more source

Additional file 7: of GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

, 2019
Table S3. Antibody information. (DOCX 13 kb)
Wen, Jia, Yan, Hao, He, Meina, Zhang, Tuo, Mu, Xinyi, Wang, Haibin, Zhang, Hua, Xia, Guoliang, Wang, Chao   +8 more
openaire   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Additional file 5: of GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

, 2019
Table S1. Genotyping primers. (DOCX 11 kb)
Wen, Jia, Yan, Hao, He, Meina, Zhang, Tuo, Mu, Xinyi, Wang, Haibin, Zhang, Hua, Xia, Guoliang, Wang, Chao   +8 more
openaire   +1 more source

The Key Roles of GSK-3β in Regulating Mitochondrial Activity

Cellular Physiology and Biochemistry, 2017
Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, has been reported to show essential roles in molecular pathophysiology of many diseases.
Kai Yang, Zhixi Chen, Juanjuan Gao, Weimei Shi, Linfu Li, Shan Jiang, Haibo Hu, Zhiping Liu, Daohua Xu, Longhuo Wu   +9 more
doaj   +1 more source

Additional file 6: of GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

, 2019
Table S2. ChIP-qPCR primers. (DOCX 11 kb)
Wen, Jia, Yan, Hao, He, Meina, Zhang, Tuo, Mu, Xinyi, Wang, Haibin, Zhang, Hua, Xia, Guoliang, Wang, Chao   +8 more
openaire   +1 more source

Additional file 3: of The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

, 2018
Table S3. Primary antibodies used for the western blot, immunohistochemistry and immunofluorescence analyses. (DOCX 15 kb)
Qiu, Wen-Ze, Zhang, Hai-Bo, Xia, Wei-Xiong, Ke, Liang-Ru, Yang, Jing, Yu, Ya-Hui, Liang, Hu, Huang, Xin-Jun, Liu, Guo-Ying, Li, Wang-Zhong, Xiang, Yan-Qun, Kang, Tie-Bang, Guo, Xiang, Lv, Xing   +13 more
openaire   +1 more source

Additional file 1: of The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling

, 2018
Table S1. Median and range of the IRS for each antibody. (DOCX 13 kb)
Qiu, Wen-Ze, Zhang, Hai-Bo, Xia, Wei-Xiong, Ke, Liang-Ru, Yang, Jing, Yu, Ya-Hui, Liang, Hu, Huang, Xin-Jun, Liu, Guo-Ying, Li, Wang-Zhong, Xiang, Yan-Qun, Kang, Tie-Bang, Guo, Xiang, Lv, Xing   +13 more
openaire   +1 more source