Results 31 to 40 of about 33,200 (128)

Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways

Frontiers in Endocrinology, 2014
Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular ...
Colleen M Bartman, Jennifer eEgelston, Sravya eKattula, Leigh C Zeidner, Anthony eD'Ippolito, Bradley W Doble, Christopher J Phiel   +6 more
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Molecular docking study of xylogranatins binding to glycogen synthase kinase-3β

Digital Chinese Medicine, 2022
Objective: The mangrove tree Xylocarpus granatum J. Koenig (X. granatum) is a medicinal plant used to treat various diseases in several Asian countries.
Christian Bailly, Gérard Vergoten
doaj   +1 more source

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord

Basic and Clinical Neuroscience, 2020
Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-
Mina Rashvand, Samira Danyali, Homa Manaheji   +2 more
doaj  

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Neural Plasticity, 2019
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity.
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec   +2 more
doaj   +1 more source

Glycogen Synthase Kinase-3 Beta Expression Correlates With Worse Overall Survival in Non-Small Cell Lung Cancer—A Clinicopathological Series

Frontiers in Oncology, 2021
BackgroundGlycogen Synthase Kinase-3 beta (GSK-3β) regulates diverse cell functions including metabolic activity, signaling and structural proteins. GSK-3β phosphorylates target pro-oncogenes and regulates programmed cell death-ligand 1 (PD-L1).
Marclesson Alves, Daniela de Paula Borges, Aline Kimberly, Aline Kimberly, Francisco Martins Neto, Ana Claudia Oliveira, Juliana Cordeiro de Sousa, Juliana Cordeiro de Sousa, Cleto D. Nogueira, Cleto D. Nogueira, Benedito A. Carneiro, Fabio Tavora, Fabio Tavora, Fabio Tavora   +13 more
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GSK-3β in Dendritic Cells Exerts Opposite Functions in Regulating Cross-Priming and Memory CD8 T Cell Responses Independent of β-Catenin

Vaccines
GSK-3β plays a critical role in regulating the Wnt/β-catenin signaling pathway, and manipulating GSK-3β in dendritic cells (DCs) has been shown to improve the antitumor efficacy of DC vaccines.
Chunmei Fu, Jie Wang, Tianle Ma, Congcong Yin, Li Zhou, Björn E. Clausen, Qing-Sheng Mi, Aimin Jiang   +7 more
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GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

Scientific Reports, 2017
Increasing evidence suggests that glycogen synthase kinase-3β (GSK-3β) plays a crucial role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also shows detrimental effects. Currently, the function of GSK-3β in specific type
Enjie Liu, Ao-Ji Xie, Qiuzhi Zhou, Mengzhu Li, Shujuan Zhang, Shihong Li, Weijin Wang, Xiaochuan Wang, Qun Wang, Jian-Zhi Wang   +9 more
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GSK-3β and Vitamin D Receptor are Involved in β-Catenin and Snail Signaling in High Glucose-Induced Epithelial-Mesenchymal Transition of Mouse Podocytes

Cellular Physiology and Biochemistry, 2014
Background: Epithelial-mesenchymal transition (EMT) is recognized to play an important role in diabetic nephropathy (DN). Objective: To analyze the roles of glycogen synthase kinase 3β (GSK-3β), β-catenin and Snail signaling in high glucose (HG)-induced ...
Jia Guo, Nannan Xia, Lili Yang, Sijie Zhou, Qian Zhang, Yingjin Qiao, Zhangsuo Liu   +6 more
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TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target

Acta Pharmaceutica Sinica B, 2021
Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3β (GSK-3β) interacts with and inactivates the ...
Shanshan Liu, Xiaoxi Lv, Xupeng Wei, Chang Liu, Qiao Li, Jiali Min, Fang Hua, Xiaowei Zhang, Ke Li, Pingping Li, Yang Xiao, Zhuowei Hu, Bing Cui   +12 more
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Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer’s disease (AD) pathology. A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesised and evaluated as potential GSK-3β ...
Ning Yan, Xiao-Long Shi, Long-Qian Tang, De-Feng Wang, Xun Li, Chao Liu, Zhao-Peng Liu   +6 more
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