Results 11 to 20 of about 33,158 (224)
The rs140668532 SNP in GSK-3β gene as a potential biomarker for Alzheimer’s disease: Insights from computational modeling [PDF]
Toxicology ReportsGlycogen synthase kinase-3 beta (GSK-3β) is well recognized for its role in diverse physiological processes, including apoptosis, mitochondrial function, and gene transcription regulation.
İrem Gülfem Albayrak +1 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2020 Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD).
Shanshan Ma +2 more
exaly +3 more sources
EBioMedicine, 2022 Summary: Background: Glycogen synthase kinase-3β (GSK-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation in Alzheimer's disease (AD).
Qiuzhi Zhou +9 more
doaj +1 more source
New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis [PDF]
PeerJ, 2023 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions and is inactivated upon stimulation. In mammals, GSK-3 includes GSK-3 α and GSK-
Shenjin Lai +3 more
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Glycogen synthase kinase-3β is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma. [PDF]
PLoS ONE, 2014 BACKGROUND: Although many studies have shown glycogen synthase kinase-3β (GSK-3β) was associated with type 2 diabetes mellitus (T2DM) and implicated with a wide range of cancers, the role of GSK-3β in hepatocellular carcinoma(HCC) and the correlation ...
Guoliang Qiao +4 more
doaj +1 more source
Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion. [PDF]
PLoS ONE, 2013 Glioma malignancy greatly depends on its aggressive invasion. The establishment of cell polarity is an important initial step for cell migration, which is essential for cell-directional translocation.
Qifei Zou +3 more
doaj +1 more source
Biomedicines, 2021 The adverse effect of cisplatin administration causes acute kidney injury (AKI) following renal inflammation and nephrotoxicity, characterized by proximal tubular cell apoptosis and necrosis.
Chung-Hsi Hsing +6 more
doaj +1 more source
GSK-3β, a pivotal kinase in Alzheimer disease [PDF]
Frontiers in Molecular Neuroscience, 2014 Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of AD is considered to be multifactorial as only a negligible percentage of cases have a familial or genetic origin. Glycogen synthase kinase-3 (GSK-3) is regarded as a critical molecular link between the two histopathological hallmarks of the disease, namely senile ...
Maria eLLorens-Martin +7 more
openaire +4 more sources
Memory formation in old age requires GSK-3β
Aging Brain, 2021 Glycogen synthase kinase 3β (GSK-3β) is a therapeutic target for various age-related neurodegenerative diseases. It is linked to the two main pathological features of Alzheimer’s disease (AD), tau and amyloid β (Aβ); GSK-3β is a major candidate to ...
Riki Koike +3 more
doaj +1 more source
Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
doaj +1 more source