Results 51 to 60 of about 33,200 (128)

GSK-3𝜷: A Bifunctional Role in Cell Death Pathways

International Journal of Cell Biology, 2012
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular ...
Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala   +5 more
doaj   +1 more source

PI3K Mediated Activation of GSK-3β Reduces At-Level Primary Afferent Growth Responses Associated with Excitotoxic Spinal Cord Injury Dysesthesias

Molecular Pain, 2015
Background Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the development of post SCI pain ...
Sonja K Bareiss, Elizabeth Dugan, Kori L Brewer   +2 more
doaj   +1 more source

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

Molecules, 2013
A series of novel 3-benzisoxazolyl-4-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high inhibitory potency towards GSK-3β.
Jianrong Gao, Weisi Wang, Yujin Li, Liang Han, Lei Xu, Jiayi Cao, Tao Pang, Yubo Zhou, Meng Li, Qing Ye, Jia Li   +10 more
doaj   +1 more source

MiR-27a Facilitates Breast Cancer Progression via GSK-3β

Technology in Cancer Research & Treatment, 2020
Breast cancer remains one of the leading causes of cancer-associated death in women. MiR-27a is highly expressed in breast cancer tissue. However, the underlying mechanisms that promote breast cancer progression are unknown.
Huijin Chen BA, Yuanyuan Zhang BA, Xin Cao BA, Peipei Mou BA   +3 more
doaj   +1 more source

Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin α5

Stem Cell Research & Therapy, 2018
Background Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an important regulatory factor for hMSC ...
Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li, Yulin Li   +9 more
doaj   +1 more source

Molecular cloning and transcriptional and functional analysis of glycogen synthase kinase-3β in Haemaphysalis longicornis (Acari, Ixodidae)

Parasite, 2019
Glycogen synthase kinase 3 (GSK-3), which belongs to the serine/threonine kinase family, regulates glycogen metabolism, Wnt signaling, hormonal regulation, and embryonic development in many eukaryotes.
Rahman Md. Khalesur, You Myungjo
doaj   +1 more source

Glycogen synthase kinase-3β inhibition induces nuclear factor-κB-mediated apoptosis in pediatric acute lymphocyte leukemia cells

Journal of Experimental & Clinical Cancer Research, 2010
Background Molecular therapies that target genetic abnormalities in leukemic cells and their affected signaling pathways have been emerging in pediatric acute lymphoblastic leukemia (ALL).
Luo Qing, Li Ruiyan, Gu Xiaoyan, Hu Yanni, Xu Youhua   +4 more
doaj   +1 more source

Navigating the GSK-3β inhibitors as versatile multi-target drug ligands in Alzheimer’s disease intervention – A comprehensive review

Results in Chemistry
Alzheimer’s disease (AD) remains a significant global health challenge, necessitating the exploration of novel therapeutic strategies. AD is a neurodegenerative disease characterized by the formation of amyloid-β (Aβ) plaques and neurofibrillary tangles ...
Nachiket Jitendra Joshi, Alavala Raja Sekhar Reddy   +1 more
doaj   +1 more source

Keap1-independent GSK-3β/Nrf2 signaling mediates electroacupuncture inhibition of oxidative stress to induce cerebral ischemia-reperfusion tolerance

Brain Research Bulletin
Purpose: Cerebral ischemia-reperfusion (CIR) injury is a devastating consequence of stroke characterized by oxidative stress-induced neuronal damage. Electroacupuncture (EA) has emerged as a potential therapeutic intervention for ischemic stroke, but its
Chunjue Ni, Baojun Huang, Yufan Huang, Zhengde Wen, Shan Luo   +4 more
doaj   +1 more source

Pharmacological Targeting of PI3K/Akt/mTOR and Wnt/GSK-3β Signaling in Oligodendrocyte Differentiation and Remyelination. [PDF]

Cells
Kim ME, Lee JS.
europepmc   +1 more source