Results 1 to 10 of about 61,359 (156)

Platelet glycogen synthase kinase 3β regulates plasma β amyloid and phosphorylated tau levels in chronic kidney disease patients with cognitive dysfunction; therapeutic role of erythropoietin [PDF]

Journal of Nephropathology, 2023
Introduction: Patients with chronic kidney disease (CKD) have increasingly been diagnosed with cognitive impairment. Glycogen synthase kinase 3β (GSK3β) is directly causing both phosphorylated tau (pTau) and amyloid β (Aβ) accumulation in Alzheimer’s ...
Vinothkumar Ganesan, Krishnakumar Sethuraman, Sureshkumar Sureshkumar, Venkataraman Prabhu   +3 more
doaj   +1 more source

The Effect of Xenon on the Activity of Glycogen Synthase Kinase-Зβ in the Perifocal Zone of Ischemic Cerebral Infarction (Experimental Study)

Общая реаниматология, 2023
Aim of the study. To determine the effects of xenon exposure at a dose of 0.5 MAC of different duration on the content and enzyme-inactivating phosphorylation of the glycogen synthase kinase-3β (GSK3β) in the perifocal zone of ischemic cerebral ...
A. V. Ershov, I. A. Krukov, V. V. Antonova, A. A. Baeva   +3 more
doaj   +1 more source

Cordycepin Suppresses The Malignant Phenotypes of Colon Cancer Cells through The GSK3ß/ß-catenin/cyclin D1 Signaling Pathway [PDF]

Cell Journal, 2022
Objective: Cordycepin, also known as 3ˊ-deoxyadenosine, is the main bioactive ingredient of Cordyceps militaris and possesses various pharmacological effects.
Jie Xu, Xia Shen, Daozhong Sun, Yanjie Zhu   +3 more
doaj   +1 more source

Epibrassinolide Triggers Apoptotic Cell Death in SK-N-AS Neuroblastoma Cells by Targeting GSK3β in a ROS Generation-Dependent Way

European Journal of Biology, 2022
Objective: Epibrassinolide (EBR), a biologically active member of the brassinosteroids plant hormone family, has been recently indicated as an apoptotic inducer in various cancer cells without affecting non-tumor cell proliferation.
Pınar Obakan Yerlikaya, Shafaq Naxmedova   +1 more
doaj   +1 more source

Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients

OncoImmunology, 2022
Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells.
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher, Sean R.R. Hall   +16 more
doaj   +1 more source

Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma [PDF]

Obstetrics & Gynecology Science, 2019
ObjectiveThis study aimed to analyze the expression pattern of glycogen synthase kinase 3β (GSK3β) and its phosphorylated forms, GSK3β phosphorylated at Ser9 (pS9GSK3β), and GSK3β phosphorylated at Tyr216 (pY216GSK3β), in cervical squamous cell carcinoma
Kwanghee Ahn, Sojung Kweon, Dae Woon Kim, Hojung Lee   +3 more
doaj   +1 more source

GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness

Cells, 2020
Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell.
Przemysław Duda, Daria Hajka, Olga Wójcicka, Dariusz Rakus, Agnieszka Gizak   +4 more
doaj   +1 more source

Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

Molecules, 2022
In the present study, we investigated the molecular mechanisms of adenosine for its hair growth promoting effect. Adenosine stimulated the Wnt/β-catenin pathway by modulating the activity of Gsk3β in cultured human dermal papilla cells. It also activated
Jaeyoon Kim, Jae Young Shin, Yun-Ho Choi, Nae Gyu Kang, Sanghwa Lee   +4 more
doaj   +1 more source

SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells

Animal Cells and Systems, 2020
SIRT1, the best-characterized member of the sirtuin family of deacetylases, is involved in cancer, apoptosis, inflammation, and metabolism. Active regulator of SIRT1 (AROS) was the first identified direct regulator of SIRT1.
Jeong Woo Kim, Ji Hye Yang, Eun-Joo Kim
doaj   +1 more source

GSK3β isoform‐selective regulation of depression, memory and hippocampal cell proliferation [PDF]

Genes, Brain and Behavior, 2016
Abnormally active glycogen synthase kinase‐3 (GSK3) contributes to pathological processes in multiple psychiatric and neurological disorders. Modeled in mice, this includes increasing susceptibility to dysregulation of mood‐relevant behaviors, impairing performance in several cognitive tasks and impairing adult hippocampal neural precursor cell (NPC ...
Pardo, Marta, Abrial, E., Jope, R.S., Beurel, E.   +3 more
openaire   +3 more sources