Results 41 to 50 of about 70,328 (289)

The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism

Bezmiâlem Science, 2022
Following increased epidemiological studies indicating the relationship between diabetes and Alzheimer’s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology.
Rabia DURAN, Sümeyra PANCUR, Fatemeh BAHADORİ   +2 more
doaj   +1 more source

Supplementary Figure S1. Densitometric analysis of total β-catenin, active β-catenin, AurKA, p-AktSer473, p-GSK3βSer9 and p-Mcl-1Ser159 expression. from Loss of PKCδ Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/β-Catenin Pathway and Mcl-1 Accumulation

, 2023
<p>PKCÎ'-silenced PC3 (a) and LNCaP (b) cells were treated with DMSO or paclitaxel 2.5 µM 48 hours. Histograms show densitometric and statistical analysis of indicated proteins from panels (c) and (d) of the Figure 3. Data are presented as mean{plus minus}S.E.M.
Carmen Sáez, Miguel A. Japón, Francisco Romero, Begoña Pérez-Valderrama, Rafael Medina, Jessica Gasca, Carolina Castilla, M. Luz Flores   +7 more
openaire   +1 more source

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2. [PDF]

, 2016
CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue.
Calabretta, Bruno, Canonico, Pier Luigi, Condorelli, Fabrizio, De Dominici, Marco, Genazzani, Armando A, Gnemmi, Ilaria, Mariani, Samanta A., Minassi, Alberto, Minieri, Valentina, Riva, Beatrice, Salomoni, Paolo   +10 more
core   +2 more sources

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway

Cancer Biology & Medicine, 2020
Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner. Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.
Yue Yuan*, Yanling Fan*, Zicong Gao, Xuan Sun, He Zhang, Zhiyong Wang, Yanfen Cui, Weijie Song, Zhaosong Wang, Fei Zhang, Ruifang Niu   +10 more
doaj   +1 more source

A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. [PDF]

, 2007
Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signaling and thus inhibits osteogenesis.
Angela Smolarz, Carl Gregory, Darwin Prockop, Edwin Horwitz, Jacob Reiser, Najat Daw, Narae Lee, Odile David, Robert Kutner, Scott Olson   +9 more
core   +3 more sources

Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

Pharmaceutical Biology, 2021
Context Ferroptosis was described as an important contributor to the myocardial ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and anti-inflammatory activities. Objective Our study explores the effect and mechanism
Haoyang Lu, Hui Xiao, M. Dai, Y. Xue, Ren Zhao   +4 more
semanticscholar   +1 more source

Cancer associated fibroblasts secreted exosomal miR-1290 contributes to prostate cancer cell growth and metastasis via targeting GSK3β

Cell Death Discovery, 2022
Cancer-associated fibroblasts (CAFs) play crucial roles in mediating tumor growth and metastasis via transferring exosomes to neighboring cells, whereas the mechanisms by which CAFs regulate the tumorgenesis of prostate cancer (PC) remain largely unknown.
Shuo Wang, P. Du, Yudong Cao, Jinchao Ma, X. Yang, Ziyi Yu, Yong Yang   +6 more
semanticscholar   +1 more source

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

Assessing the Role of GSK3 β and Arrestin Beta1 in Regulating Oxidative Stress that Causes Metabolic Disorders [PDF]

Kirkuk Journal of Science
Metabolic syndrome is intricately associated with diabetes and obesity. Elevated obesity fosters inflammation and oxidative stress, which are precursors to several problems, including elements of metabolic disorders such as insulin resistance and hyper ...
Asmaa Abd, Fayhaa Khaleel
doaj   +1 more source

Hair growth potential of Salvia plebeia extract and its associated mechanisms

Pharmaceutical Biology, 2020
Context Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.
Guang-Ri Jin, Yi-Lin Zhang, Jonathan Yap, William A. Boisvert, Bog-Hieu Lee   +4 more
doaj   +1 more source