Results 51 to 60 of about 70,328 (289)

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

eLife, 2023
Multiple signaling pathways regulate the kinase GSK3β by inhibitory phosphorylation at Ser9, which then occupies the GSK3β priming pocket and blocks substrate binding.
Maire Gavagan, Noel Jameson, Jesse G Zalatan   +2 more
doaj   +1 more source

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia [PDF]

, 2018
Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment.
Bellini, Maria Jose, Capani, Francisco, Garcia Segura, Luis Miguel, Saraceno, Gustavo Ezequiel   +3 more
core   +2 more sources

Glycogen synthase kinase 3β promotes osteogenic differentiation of murine adipose-derived stromal cells. [PDF]

PLoS ONE, 2013
Although the role of glycogen synthase kinase 3β (GSK3β) in osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs) is well-characterized as a negative regulator of β-catenin, its effect on osteogenesis of adipose-derived ...
Jeong-Eun Huh, Ryeojin Ko, Hyun Ju Jung, Soo Young Lee   +3 more
doaj   +1 more source

Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways

Frontiers in Medicine, 2021
Background and Objective: Diabetes mellitus (DM) is reportedly a significant risk factor for intervertebral disc degeneration (IDD). Incretin system and particularly glucagon-like peptide 1 (GLP-1) because of its glucose-lowering effects has become an ...
Ming-Yan Yao, Jing Zhang, Zhihong Li, Xiaoliang Bai, Jinhui Ma, Yukun Li   +5 more
semanticscholar   +1 more source

Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation

Journal of Pharmacological Sciences, 2017
Methyleugenol (Mlg), a natural ingredient of many herbs and used as a flavoring substance in dietary products, inhibits inflammation and oxidative stress. The aim of the study is to explore the antioxidative potential of Mlg against tert-butyl hydroperoxide (t-BHP)-triggered oxidative injury and the involvement of antioxidative mechanisms. Our findings
Junfeng Zhou, Xiaoyuan Ma, Yan Cui, Yang Song, Lei Yao, Yuanyuan Liu, Shanshan Li   +6 more
openaire   +3 more sources

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Cancer Cell, 2019
Tumor cells may adapt to metabolic challenges by alternating between glycolysis and oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined intermittent fasting, a clinically feasible approach to reduce glucose availability ...
Mohamed Elgendy, M. Ciró, A. Hosseini, J. Weiszmann, L. Mazzarella, Elisa Ferrari, R. Cazzoli, G. Curigliano, A. Decensi, B. Bonanni, A. Budillon, P. Pelicci, V. Janssens, M. Ogris, M. Baccarini, L. Lanfrancone, W. Weckwerth, M. Foiani, S. Minucci   +18 more
semanticscholar   +1 more source

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells

PLoS ONE, 2021
Glycogen-specific kinase (GSK3β) is an integral regulator of the Wnt signalling pathway as well as many other diverse signalling pathways and processes.
Emily Bowler-Barnett, Francisco D. Martinez-Garcia, Matthew Sherwood, Ahood Aleidan, Steve John, Sara Weston, Yihua Wang, Nullin Divecha, Paul Skipp, Rob M. Ewing   +9 more
doaj   +2 more sources

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott, Averous, Avruch, Azoulay-Alfaguter, Bain, Bar-Peled, Bar-Peled, Bradford, Carriere, Carriere, Clare Stretton, Coghlan, Cross, Demetriades, Dibble, Doble, Fonseca, Foster, Frey, Ganley, Garcia-Martinez, Gwinn, Gwinn, Hajduch, Hara, Harinder S. Hundal, Hosokawa, Ian G. Ganley, Inoki, Inoki, Inoki, Jewell, Jung, Kelleher, Kim, Kim, Kwak, Lipina, MacAulay, Marchand, Martina, Meijer, Menon, Michael J. Munson, Oshiro, Oshiro, Parr, Peter M. Taylor, Pfaffl, Ramirez-Valle, Rebsamen, Sancak, Shin, Smith, Stretton, Sutherland, Thorsten M. Hoffmann, Wang, Wang, Yoon, Zoncu   +60 more
core   +3 more sources

Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO‐mediated MZF1/c‐Myc axis

Journal of Cellular and Molecular Medicine, 2021
Colorectal carcinoma (CRC) poses heavy burden to human health and has an increasing incidence. Currently, the existing biomarkers for CRC bring about restrained clinical benefits.
Zeyan Zhang, Qianfu Gao, Shanchao Wang
semanticscholar   +1 more source

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

OncoImmunology, 2019
In patients with cancer, the functionality of Dendritic Cells (DC) is hampered by high levels of tumor-derived suppressive cytokines, which interfere with DC development and maturation.
Marta López González, Dinja Oosterhoff, Jelle J. Lindenberg, Ioanna Milenova, Sinead M. Lougheed, Tania Martiáñez, Henk Dekker, Dafne Carolina Alves Quixabeira, Basav Hangalapura, Jos Joore, Sander R. Piersma, Victor Cervera-Carrascon, Joao Manuel Santos, Rik J. Scheper, Henk M.W. Verheul, Connie R. Jiménez, Rieneke Van De Ven, Akseli Hemminki, Victor W. Van Beusechem, Tanja D. De Gruijl   +19 more
doaj   +1 more source