Results 81 to 90 of about 70,328 (289)

GSK3β and Tau Protein in Alzheimer’s Disease and Epilepsy

Frontiers in Cellular Neuroscience, 2020
Alzheimer’s disease (AD) is the most common form of dementia present in older adults; its etiology involves genetic and environmental factors. In recent years, epidemiological studies have shown a correlation between AD and chronic epilepsy since a ...
Danira Toral-Rios, Pavel Pichardo-Rojas, M. Alonso-Vanegas, V. Campos-Peña   +3 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb. [PDF]

PLoS ONE, 2013
Glycogen synthase kinase 3β (GSK3β), a multifaceted kinase, is abundantly expressed in the brain, including the olfactory bulb (OB). In resting cells, GSK3β is constitutively active, and its over-activation is presumably involved in numerous brain ...
Zhixiang Xu, Li Wang, Guo Chen, Xiaoping Rao, Fuqiang Xu   +4 more
doaj   +1 more source

Additional file 2: of GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

, 2019
Data S2. Summary of results from the high-throughput screen and the detailed red/green readout for each drug tested in the screen. (PDF 3424â kb)
Vijay, Geraldine, Zhao, Na, Hollander, Petra, Toneff, Mike, Joseph, Robiya, Pietila, Mika, Taube, Joseph, Sarkar, Tapasree, Ramirez-Pena, Esmeralda, Werden, Steven, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey, Soundararajan, Rama, Rosen, Jeffrey, Mani, Sendurai   +20 more
openaire   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
A Cole, A Hay-Koren, A Sarshad, A Vintermist, A-S Tseng, AA Sérandour, AC O'Sullivan, Aishe A. Sarshad, AM Al-Khouri, Anne Von Euler, Bader Al-Muzzaini, CJ Fiol, D Drygin, D Wu, Douglas Lamont, DW Young, E Cavellán, E Kinoshita, E Sanij, F Mohn, GE Zentner, I Grummt, J Grisouard, J Russell, J Ye, JR Woodgett, JR Woodgett, JR Woodgett, L Meijer, Laura Borgonovo-Brandter, LC Fuentealba, M Benavides, M Liu, M Rosner, M Welcker, MA Munoz, Martin Corcoran, N Fomproix, N Visa, Neus Visa, NG Kim, P Cohen, P de Lanerolle, P Percipalle, P Percipalle, Piergiorgio Percipalle, Raffaella Santoro, RS Jope, S Boulon, T Moss, T Tasaki, T Vincent, V Stambolic, VA Smits, VF Taelman, VV Philimonenko, VW Ding, WJ Ryves, YC Tsai   +58 more
core   +5 more sources

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
BACKGROUND Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Dexamethasone (Dex), a type of glucocorticoids (GCs), induces apoptosis of osteoblasts and leads to the occurrence of non-traumatic osteonecrosis.
Shuang Deng, Guo Dai, Sen Chen, Zhigang Nie, Jianlin Zhou, Hong-song Fang, Hao Peng   +6 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility [Corrigendum]

Pharmacogenomics and Personalized Medicine, 2020
Wang B, Wang M, Li X, Yang M, Liu L. Pharmgenomics Pers Med. 2020;13:157—165. Page 157, Abstract, Results section, the text “The mutant alleles of rs3864004 (A) and rs2293303 (T) located in CTNNB1 showed 1.513 (1.038–2 ...
Wang B, Wang M, Li X, Yang M, Liu L
doaj  

Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β

Mediators of Inflammation, 2020
Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation of GSK3β is associated with inflammatory responses.
Yingui Li, Yijing Zhao, Xiaoqin Tan, Jiayan Liu, Yingkun Zhi, Lang Yi, Shasha Bai, Qun Du, Qing X. Li, Yan Dong   +9 more
doaj   +1 more source

Additional file 1: of Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

, 2018
Table S1. Slit3 expression and patient characteristics in cohort 1. Table S2. Slit3 expression and patient characteristics in cohort 2. (PDF 78 kb)
Lui Ng, Chow, Ariel, Man, Johnny, Yau, Thomas, Wan, Timothy, Iyer, Deepak, Kwan, Virginia, Poon, Ronnie, Pang, Roberta, Wai-Lun Law   +9 more
openaire   +1 more source