Results 131 to 140 of about 5,937 (164)

GSTM1 copy number and lung cancer risk

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009
The GSTM1 null genotype is associated with a small increased lung cancer risk when compared to controls with at least one copy of the GSTM1 gene. As two copies of the GSTM1 gene might provide more protection than a single copy, we have determined GSTM1 copy number in a lung cancer case-control study.
Philip A J, Crosbie, Philip V, Barber, Kathryn L, Harrison, Alan R, Gibbs, Raymond M, Agius, Geoffrey P, Margison, Andrew C, Povey   +6 more
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Influence of GSTT1 and GSTM1 Genotypes on Sunburn Sensitivity

American Journal of PharmacoGenomics, 2002
Exposure to sunlight may cause sunburn, skin cancer or phototoxic reactions to certain drugs such as Hypericum extract. All these are ultraviolet B (UVB)-mediated reactions which may be modulated by individual genetic susceptibility. UVB exposure results in oxidative stress. Many products of oxidative stress are detoxified by glutathione-S-transferases
Reinhold, Kerb, Jürgen, Brockmoller, Robert, Schlagenhaufer, Raimund, Sprenger, Ivar, Roots, Ulrich, Brinkmann   +5 more
openaire   +2 more sources

GSTT1 and GSTM1 gene polymorphisims in sarcoidosis.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2016
Sarcoidosis is a granulomatous disease of unknown cause, which affects all systems, especially the lungs and the lymphatic system. Genetic and environmental factors are held accountable for the etiology. Based on the general opinion, sarcoidosis develops after exposure to a specific environmental agent by genetically susceptible individuals.
COŞKUN, NECMİYE FUNDA, Uzaslan, Esra, Yakut, Tahsin, Yilmaz, Dilber, Karkucak, Mutlu   +4 more
openaire   +2 more sources

Analysis of GSTM1, GSTT1, and CYP1A1 in Idiopathic Male Infertility

Reproductive Sciences, 2012
Enzymes belonging to the glutathione-S-transferase (GST) and cytochrome P450 (CYP) families are involved in a 2-stage detoxification process of a wide range of environmental toxins and carcinogens. In order to investigate whether there is a genetic association of the biotransformation enzymes and idiopathic male fertility, we studied GSTT1, GSTM1, and ...
Zivar, Salehi, Lida, Gholizadeh, Hamidreza, Vaziri, Ali Hamidi, Madani   +3 more
openaire   +2 more sources

[Relation of GSTM1 Polymorphism with Leukemia].

Zhongguo shi yan xue ye xue za zhi, 2018
To investigate the relation of GSTM1 polymorphism in leukemia patients with therapeutic efficacy and the main biological characteristics.The GSTM1 genotypes were detected by nested PCR; the remission rate after 1 course of treatment and main biological characteristics at occurrence of leukemia were compared between AL patients with different GSTM1 ...
Juan, Li, Jun-Fang, Zhu, Wei, Zhang, Bei, Liu, Hai-Zhen, Ma   +4 more
openaire   +1 more source

GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk

Breast Cancer Research and Treatment, 2002
Glutathione S-transferases (GSTs) are a family of important enzymes involved in the detoxification of a wide variety of known and suspected carcinogens, including potential mammary carcinogens identified in charred meats and tobacco smoke. A substantial proportion of the Caucasian population has a homozygous deletion (null) of the GSTMI or GSTT1 gene ...
Wei, Zheng, Wan-Qing, Wen, Deborah R, Gustafson, Myron, Gross, James R, Cerhan, Aaron R, Folsom   +5 more
openaire   +2 more sources

GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis

Annals of Allergy, Asthma & Immunology, 2010
The increase in the prevalence of atopic dermatitis (AD) is likely to involve changes in specific environmental exposures among genetically susceptible individuals.To evaluate the effect of glutathione S-transferase (GST) genotype polymorphisms and prenatal smoke exposure on pediatric AD on the basis of the cord blood cotinine levels.We conducted a ...
I-Jen, Wang, Yueliang Leon, Guo, Tien-Jen, Lin, Pau-Chung, Chen, Yu-Nian, Wu   +4 more
openaire   +2 more sources

GSTM1 and mEPHX Polymorphisms in Parkinson's Disease and Age of Onset

Biochemical and Biophysical Research Communications, 2000
Both environmental and genetic factors are involved in the development of PD and biotransformation of exogenous and endogenous compounds and may play a role in inter-individual susceptibility. Therefore, we investigated the presence of null genotypes of GSTM1, GSTT1, and two polymorphisms of mEPHX in subjects with Parkinson's disease and in a reference
A, Ahmadi, M, Fredrikson, H, Jerregârd, A, Akerbäck, P A, Fall, A, Rannug, O, Axelson, P, Söderkvist   +7 more
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GSTM1 genotypes in australian patients with NSCLC

1999
Aims: To determine if the null glutathione S transferase (GST) M1 genotype is linked to lung cancer risk and/or genetic damage in non-small cell lung cancer (NSCLC). Background: Individual susceptibility to lung cancer appears important as -1 in 8-10 lifetime smokers develop lung cancer.
Gan, R., Yang, I., Tunnicliffe, A. M., Rabnott, G. C., Bowman, R., Zimmerman, P.V., Fong, K. M.   +6 more
openaire   +2 more sources

Gender‐specific effects of NAT2 and GSTM1 in bladder cancer

Clinical Genetics, 2000
One approach for risk assessment of cancer is the evaluation of polymorphic enzymes involved in cancer using molecular tools. Phase II enzymes are involved in the detoxification of several drugs, environmental substances and carcinogenic compounds. Here, we analyzed enzymes for their putative relevance in urinary bladder cancer.
E, Schnakenberg, M, Lustig, R, Breuer, R, Werdin, R, Hübotter, K, Dreikorn, W, Schloot   +6 more
openaire   +2 more sources