Results 91 to 100 of about 16,641 (168)

Association betweenGSTPl gene promoter methylation and prostate cancer

Zhongguo aizheng zazhi, 2017
Background and purpose: Glutathione S-transferase P1 (GSTP1) protects cells from DNA damage and cancer cell formation. Inhibition of GSTP1 activity could increase susceptibility to DNA damage and increase the risk of cancer occurrence, which was ...
邢红宇, 朱明月
doaj  

GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic Diseases

, 2011
GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic DiseasesThe aim of the current preliminary case-control study was to identify glutathione S-transferase P1 (GSTP1) Ile105Val allele and genotype frequency and to evaluate its impact on ...
Marina Anđelić-Jelić, Dragan Popović, Ivan Nišević, Marija Stanković, Snežana Lukić, Aleksandra Nikolić, Dragica Radojković   +6 more
core   +1 more source

Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease

, 2007
Genetic predisposition, environmental toxins and aging contribute to Parkinson's disease (PD) multifactorial etiology. Weak environmental neurotoxic factors may accumulate over time increasing the disease risk in genetically predisposed subjects ...
Vilar, R., Taioli, E., Lechner, M. C., Coelho, H., Rivera, I., Gama, M. J., Rodrigues, E.   +6 more
core   +1 more source

Lung cancer resilience and stem cell phenotypes are enhanced through the CaMKIIα/NRF2/GSTP1 axis

, 2020
Lung cancer is the leading cause of cancer-related deaths worldwide. Cancer stem cells (CSC) constitute a small subset of cancer cells that enhance tumorigenesis, metastasis and drug resistance.
王思騏, Wang, Siqi
core  

The Prevalence of the Genetic Polymorphism of GSTM1, GSTT1 and GSTP1 and Its Relationship with Clinical Criteria of Multiple Sclerosis (MS) Patients in Tehran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2019
BACKGROUND AND OBJECTIVE: Multiple Sclerosis is the chronic inflammation of central nervous system with demyelinated lesions in the brain and spinal cord. The genetic polymorphisms associated with glutathione S-transferase enzymes involved in antioxidant
M Aliomrani, MA Sahraian, MR Khoshayand, T Danesh Seta, M Sharifzadeh, MH Ghahremani   +5 more
doaj  

Rapid analysis of GSTM1, GSTT1 and GSTP1 polymorphisms using real-time polymerase chain reaction

, 2000
Polymorphisms of glutathione transferases (GST) are important genetic determinants of susceptibility to environmental carcinogens (Rebbeck, 1997). The GSTs are a multigene family of dimeric enzymes involved in detoxification, and, in a few cases, the ...
Koch, B., Ko, Y., Brüning, T., Thier, R., Bolt, H. M., Vetter, H., Harth, V., Sachinidis, A.   +7 more
core  

Role of the glutathione S -transferase P1 (GSTP1) electrophile binding site (H-site) in protection from doxorubicin -mediated cytotoxicity

, 2005
The hypothesis addressed in this project was that novel variants of naturally occurring human glutathione S-transferase P1 (GSTP1) can be created by random mutagenesis of the GSTP1 active site to yield polypeptides with increased enzymatic activity ...
Stephenson, Susan Toole
core   +1 more source

Multiomics analysis of GSTP1 knockdown pancreatic cancer cells reveals key regulators of redox and metabolic homeostasis

Biology Open
Jenna N. Duttenhefner, Rahul R. Singh, Katherine Schmidt, Katie M. Reindl   +3 more
doaj   +1 more source

GSTP1 mediates tumor initiating cell phenotypes and drug resistance in lung cancer

, 2019
Multiple drug resistance is the most important reason for the unsatisfactory outcome of lung cancer treatment. Although tumor initiating cells (TIC) constitute a minority amongst all cancer cell populations, its effects on enhancing tumorigenicity and ...
Hsin, MKY, Wong, MP, Au, TWK, Sit, KY, Yam, JWP, Chan, MCW, Wang, S, Xiao, ZJ   +7 more
core  

GSTP1 promoter hypermethylation in prostate cancer detection: current evidence, clinical positioning, and translational gaps. [PDF]

Mol Biol Rep
Joo JL, Wong RS, Goh BH, Ng NC.
europepmc   +1 more source