Results 51 to 60 of about 9,099 (167)

Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo, George Rebello, Veron Ramsuran   +2 more
wiley   +1 more source

Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1

, 1999
Fifty-nine persons with industrial handling of low levels of acrylonitrile (AN) were studied. As part of a medical surveillance programme an extended haemoglobin adduct monitoring [N-(cyanoethyl)valine, CEV; N- (methyl)valine, MV; N-(hydroxyethyl)valine,
Brüning, Thomas, Thier, Ricarda, Lewalter, Jürgen, Kempkes, Manuela, Selinski, Silvia, Bolt, Hermann M.   +5 more
core   +1 more source

Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD

, 2010
The origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. Maternal smoking during pregnancy and low birth weight is associated with increased risk of asthma, poor lung function in adults and COPD in old age ...
Rose-Zerilli, Matthew J J, Rose-Zerilli, Matthew J.J.   +1 more
core   +1 more source

Association between null Genotypes of glutathione S-transferase M1 and T1 and susceptibility to systemic lupus erythematosus: A meta-analysis [PDF]

Scripta Medica
Oxidative stress is involved in the development of systemic lupus erythematosus (SLE). It is well known that activity of the glutathione S-transferase superfamily has a protective effect against oxidative stress.
Saadat Mostafa
doaj   +1 more source

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

GSTT1 expression protects lymphoma cells from PAH-induced DNA damage.

, 2014
A: GSTT1 gene expression assessed by semi-quantitative PCR in Namalwa and Jurkat cells transfected with GSTT1 (GSTT1) and the negative control vector (FU). B: Images represent results from three independent experiments.
Zhao-Hui Gu (386376), Jing-Yi Shi (251313), Jun-Min Li (157253), Wei-Li Zhao (26905), Fan Yang (1413), Yan Zhao (58882), Sai-Juan Chen (26907), Jie Xiong (138164), Xiao-E Jia (524987)   +8 more
core   +1 more source

Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin

Journal of Ovarian Research, 2021
Serous ovarian cancer (SOC) is the most common women cancer and the leading cause of cancer-related mortality among the gynaecological malignancies. Although effective chemotherapeutics combined with surgery are developed for the treatment, the five-year
Jing Zhang, Suhong Xie, Lei Zhou, Xiaoyu Tang, Xiaolin Guan, Minjie Deng, Hui Zheng, Yanchun Wang, Renquan Lu, Lin Guo   +9 more
doaj   +1 more source

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta‐Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence

MedComm, Volume 7, Issue 9, September 2026.
Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue, Jiahui He, Qilian Du, Xuanmei Li, Yixuan Zhou, Qiongfang Zhang, Chunyan Qi, Hong Ren, Hong‐Gang Ren   +17 more
wiley   +1 more source

Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians [PDF]

, 2005
The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by ...
Guimarães, Maria de Nazaré Klautau, Oliveira, Silviene Fabiana, Hatagima, Ana, D'Ascenção, Renata Ferreira, Grisolia, Cesar Koppe, Ferrari, Íris, D`Ascenção, Renata Ferreira, Hiragi, Cássia de Oliveira, Oliveira, Silviene Fabiana de, Grisolia, Cesar Kopke, Hatagima,Ana, Hiragi,Cássia de Oliveira, Ferrari,Íris, Oliveira,Silviene Fabiana, D'Ascenção,Renata Ferreira, Klautau-Guimarães,Maria de Nazaré, Grisolia,Cesar Koppe   +16 more
core   +1 more source

GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation. [PDF]

, 2021
PURPOSE This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing ...
Chalandon, Yves, Uppugunduri, Satyanarayana Chakradhara Rao, Robin, Shannon, Robin, Shannon Kristell Denise, paediatric diseases working party of the European society for blood and marrow transplantation, Jurkovic Mlakar, Simona, Rezgui, Mohamed-Ali, Bredius, Robert G M, Rezgui, Mohamed Aziz, Bittencourt, Henrique, Mlakar, Vid, Mlakar, Simona, Uppugunduri Satyanarayana, Chakradhara Rao, Ansari Djaberi, Marc Georges, Golay, Hadrien, Bredius, Robert G. M., Krajinovic, Maja, Waespe, Nicolas, Boelens, Jaap Jan, Peters, Christina, Ansari, Marc, Corbacioglu, Selim, Nava, Tiago, Dalle, Jean-Hugues, Christina Peters, Robert G. M. Bredius, Hadrien Golay, Selim Corbacioglu, Marc Ansari, Jean-Hugues Dalle, Nicolas Waespe, Vid Mlakar, Henrique Bittencourt, Simona Jurkovic Mlakar, Yves Chalandon, Maja Krajinovic, Jaap Jan Boelens, Shannon Robin, null null, Tiago Nava, Satyanarayana Chakradhara Rao Uppugunduri, Mohamed Aziz Rezgui   +41 more
core   +2 more sources