Results 91 to 100 of about 190,941 (249)

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

An Orthogonal Way of Writing the Tubulin Code

Cytoskeleton, EarlyView.
ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero, Emmanuel Derivery   +1 more
wiley   +1 more source

Prolonged oral intake of green tea polyphenols attenuates delirium-like behaviors in mice induced by anesthesia/surgery

Heliyon
Postoperative delirium (POD) is a severe postoperative complication characterized by delirium-like symptoms. So far, no effective preventable strategy for POD prevention has been identified. Reports show that the consumption of green tea polyphenols (GTP)
Yao Xue, Yan-Na Zhang, Man Wang, Hui-Yuan Fu, Ying-Chao Mao, Min Hu, Mei-Tao Sun, Hong-Gang Guo, Lin Cao, Chen-Zhuo Feng   +9 more
doaj   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Identification of GTP‐Binding Proteins by ADP‐Ribosylation in the Presence of Cholera Toxin, Pertussis Toxin and Botulinum Toxin D in Plasma Membrane Isolated from Eggs and Embryos of Sea Urchin [PDF]

, 1992
Yasuyuki Kamata, Shigehisa Furuya, Kaori Takei‐Mikami, Akiko Fujiwara, Ikuo Yasumasu   +4 more
openalex   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Extraction, Characterization, and Impact of Polysaccharides From Zhonghuang No. 1 Etiolated‐Green Tea on Human Fecal Microbiota

Food Bioengineering
Tea polysaccharides have attracted widespread attention in regulating gut microbiota. A highly efficient enzymolysis and ultrasonic‐assisted extraction method was developed and optimized for the extraction of polysaccharides from Zhonghuang No.
Baoming Tian, Xue Zhou, Shuo Pan, Wei Liu   +3 more
doaj   +1 more source

Location of the gene coding for GTP cyclohydrolase I on the physical map of Escherichia coli [PDF]

, 1993
Harald Ritz, Günter Keller, Gerald Richter, Gerd Katzenmeier, Adelbert Bacher   +4 more
openalex   +1 more source