Results 231 to 240 of about 328,032 (283)

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Effects of high‐intensity interval training on cardiac function in hypertensive and normotensive men: Effects of antihypertensive treatment

Experimental Physiology, EarlyView.
Abstract Exercise training is recommended for individuals with hypertension because it has been shown to lower blood pressure and reverse left ventricular concentric remodelling and mass. However, it is unclear how hypertensive individuals respond in comparison to normotensive individuals and to what extent medical treatment affects the outcome of ...
Mads Fischer, Jon Egelund, Matteo Fiorenza, Thomas S. Ehlers, Michael Nyberg, Jesper J. Linde, Lasse Gliemann, Thomas P. Gunnarsson, Jens Bangsbo   +8 more
wiley   +1 more source

Systematic and precise interventions for KRAS-mutant cancers. [PDF]

Exp Hematol Oncol
Liang J, Wu J, Zhang Y, Wang H, Zheng Y, He Q.   +5 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

GTP cycling protein (GCP): An ancient player for allosteric gatekeeping. [PDF]

mLife
Liu JL.
europepmc   +1 more source

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

Dynamic Monitoring of Content Variation of Guanosine Triphosphate in Single Cells under External Stimulus with Functionalized Fluorescent/Photothermal Nb₂C‑MXene Nanoprobes. [PDF]

Chem Biomed Imaging
Guan X, Zhao W, Li W, Luo Y, Yang L, Ni H, Chen L, Wang B, Jin Y.   +8 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

ARAP1 fine-tunes F-actin polymerization level in lymphocytes through RhoA inhibition. [PDF]

Front Immunol
Ueda Y, Kondo N, Kamioka Y, Kinashi T.
europepmc   +1 more source