Results 161 to 170 of about 81,307 (285)

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene. [PDF]

Cancer Gene Ther
Mirzaiebadizi A, Ahmadian MR.
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

A New Single-Chain, Genetically Encoded Biosensor for RhoB GTPase Based on FRET, Useful for Live-Cell Imaging. [PDF]

Cells
Pagano S, Hodgson L.
europepmc   +1 more source

Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs

Journal of Anatomy, EarlyView.
The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell, Martin Minařík, David Buckley, Tanmay Anand, David Gela, Martin Pšenička, Clare V. H. Baker   +6 more
wiley   +1 more source

RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether. [PDF]

Nat Commun
Yang Z, Nakajima S, Chen H, Chakrabarty Y, Feng H, Chan DC.   +5 more
europepmc   +1 more source

Molar–Incisor and Generalized Grade C Periodontitis: Distinct Microbiome–Immune Interactions Suggest Divergent Pathogenesis

Journal of Periodontal Research, EarlyView.
Molar–Incisor (PerioC‐MIP) and Generalized (PerioC‐G) Grade C Periodontitis in systemically healthy patients exhibit different microbiological, inflammatory markers, and genomic signatures, as the analysis of subgingival content from North Americans with PerioC‐MIP and Brazilians with PerioC‐G (geographic preference of each respective phenotype ...
Camila S. Stolf, Hélvis E. S. Paz, Murilo C. Paraluppi, Manuela M. V. Miguel, Mauro P. Santamaria, Mabelle F. Monteiro, Deyvid E. Amgarten, Raquel R. A. Franco, Luciana S. Branco‐de‐Almeida, Luciana M. Shaddox, Renato C. V. Casarin   +10 more
wiley   +1 more source

Rac1 in gastric cancer: a molecular driver of invasion, EMT, and therapeutic resistance. [PDF]

J Transl Med
Li J, Zhu Y, Duan R, Tian Y, Li X, Song Y.   +5 more
europepmc   +1 more source