Results 161 to 170 of about 106,372 (251)

A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants. [PDF]

Comput Struct Biotechnol J
Cabral Oliveira C, Bassi Simoni E, Abrahão Bueno Morais M, Pacheco Batista Fontes E, Braga Dos Reis PA, Urano D, Jones AM.   +6 more
europepmc   +1 more source

Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development

The Journal of Physiology, EarlyView.
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang, Adam Fekete, Jason Arsenault, Ameet S. Sengar, Jamila Aitoubah, Giovanbattista Grande, Angela Li, Eric W. Salter, Alex Wang, Melanie D. Mark, Stefan Herlitze, Sean E. Egan, Michael W. Salter, Lu‐Yang Wang   +13 more
wiley   +1 more source

A PDZ-kinase allosteric relay mediates Par complex regulator exchange. [PDF]

J Biol Chem
Vargas E, Penkert RR, Prehoda KE.
europepmc   +1 more source

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source

The role of RAC1 in resistance to targeted therapies in cancer. [PDF]

Small GTPases
Uribe-Alvarez C, Chernoff J.
europepmc   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma. [PDF]

Eur Thyroid J
Karimi AH, Zeng PY, Cecchini M, Barrett JW, Pan H, Ying S, Le N, Mymryk JS, Ailles LE, Nichols AC.   +9 more
europepmc   +1 more source

Muscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated the role of AXIN1 and AXIN2 in regulating skeletal muscle AMP‐activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) signalling and glucose uptake. Although AXIN1 has been proposed as a key scaffold linking energy sensing to catabolic and anabolic signalling pathways in cell
Kaspar W. Persson, Roberto Meneses‐Valdés, Nicoline R. Andersen, Frederik S. Pedersen, Samantha Gallero, Sofie A. Hesselager, Carlos Henriquez‐Olguin, Thomas E. Jensen   +7 more
wiley   +1 more source

Hyperactivation of mTORC1 by an endogenous <i>raga-1</i> gain-of-function mutation does not reduce lifespan in <i>C.&nbsp;elegans</i>. [PDF]

MicroPubl Biol
Moreno TM, Brown ME, Kumsta C.
europepmc   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source