Results 161 to 170 of about 77,701 (285)
GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng+3 more
wiley +1 more source
FGF-Mediated Axon Guidance: Role of Downstream Signaling Pathways in Cytoskeletal Control. [PDF]
Li J, Gao H, Liu F.
europepmc +1 more source
Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression
Partitioning Defective 6B (PARD6B), a polarity gene, functions as a scaffold node for the Par protein complex. In this study, we showed that highly expressed PARD6B could promote CRC growth by upregulating MYC expression while suppressing miR‐34c expression.
Kosuke Hirose+18 more
wiley +1 more source
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman+11 more
wiley +1 more source
Research Advances of the Autophagy‐Regulated Radiosensitivity
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu+7 more
wiley +1 more source
EZR-PLC and RhoGTPases interactions in osteosarcoma pathogenesis and metastatic process [PDF]
LEOPIZZI, MARTINA
core
Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling. [PDF]
Jabbar J+4 more
europepmc +1 more source
Tumour Cell Size Control and Its Impact on Tumour Cell Function
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley +1 more source
Asgard Arf GTPases can act as membrane-associating molecular switches with the potential to function in organelle biogenesis. [PDF]
Zhu J+17 more
europepmc +1 more source