Results 181 to 190 of about 41,822 (243)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, Volume 600, Issue 13, Page 1859-1871, July 2026.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Regulation of NMDA receptor interactions with the actin cytoskeleton in dendritic spine development. [PDF]

Front Cell Neurosci
Lloyd J, Litwa K.
europepmc   +1 more source

New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene. [PDF]

Cancer Gene Ther
Mirzaiebadizi A, Ahmadian MR.
europepmc   +1 more source

The small GTPase Rab5 inhibits actin polymerization mediated by the Legionella pneumophila effector VipA. [PDF]

Med Microbiol Immunol
Saraiva J, Bugalhão JN, Carvalho T, Hensel Z, Crevenna A, Mota LJ, Franco IS.   +6 more
europepmc   +1 more source

Small GTP-binding proteins in the regulation of exocytosis in mast cells

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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation

Biochemical and Biophysical Research Communications, 2021
Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Byong Seo Park, Hye Li Im, Nal Ae Yoon, Thai Hien Tu, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee   +6 more
openaire   +2 more sources

Regulation of small GTP-binding proteins by insulin

Biochemical Society Transactions, 2006
Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
G I, Welsh, I, Hers, M, Wherlock, J M, Tavaré   +3 more
openaire   +2 more sources