Results 181 to 190 of about 4,439,363 (293)

Building the bridges: molecular mechanisms of tunneling nanotube formation. [PDF]

Cell Mol Life Sci
Brou C, Zurzolo C.
europepmc   +1 more source

‘In silico labelling’: Exploring the biological landscape at the nanoscale using intelligent multimodal optical microscopy

Journal of Microscopy, EarlyView.
Abstract Multimodal optical microscopy has recently converged with artificial intelligence (AI) to enable in silico labelling—the computational prediction of fluorescence‐like molecular contrast from label‐free measurements. Fluorescence plays a crucial role in linking microscopy and spectroscopy at molecular level, enabling image formation by means of
A. Diaspro, P. Bianchini, R. Bizzarri, F. Cella Zanacchi, S. Civita, N. Incardona, L. Lanzanò, A. Morgantini, M. Salerno, L. Touijer   +9 more
wiley   +1 more source

Small-molecule inhibitor of Gαo for GNAO1 encephalopathy. [PDF]

Biosci Rep
Larasati YA, Koval A, Katanaev VL.
europepmc   +1 more source

Rapid Translation of the Early Coding Region Promotes Premature Transcription Termination, Reducing Protein Expression in Escherichia coli

Molecular Microbiology, EarlyView.
A run of consecutive fast‐translated codons (right) within the first 30 codons of lacZ (top) causes loss of the downstream transcript at positions coinciding with previously mapped intragenic Rho‐dependent termination sites (middle), and a corresponding loss of β‐galactosidase activity (bottom).
Steen Pedersen, Alberte Honoré Jepsen, Bertil Gummesson, Namiko Mitarai, Kim Sneppen, Sine Lo Svenningsen   +5 more
wiley   +1 more source

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications. [PDF]

Protein Sci
Srinivasu BY, Damerla TS, Stec A, Zhou Z, Engen JR, Westover KD, Wales TE.   +6 more
europepmc   +1 more source

Targeted Modulation of Eukaryotic Release Factor 1 (OseRF1) by an RNA Aptamer Enhances Drought Adaptation in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought stress severely restricts rice productivity, necessitating strategies to enhance stress resilience. Here, we identify translation termination as a tunable regulatory node for stress adaptation. Using 25 rounds of SELEX, we isolated RTAR, an RNA aptamer that binds the rice eukaryotic release factor 1 (OseRF1) with nanomolar affinity ...
Shuangfeng Dai, Mingming Chen, Haomin Chen, Yuantao Ye, Hong Huang, Renrong Zhang, Zhenyu Guo, Yongxiang Huang   +7 more
wiley   +1 more source

Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer. [PDF]

Pharmaceuticals (Basel)
Nguyen HTN, Le BHN, Van NTH, Tran TTT, Nguyen MT.   +4 more
europepmc   +1 more source

Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males

Experimental Physiology, EarlyView.
Abstract Exercise and nutritional modulation favourably alter mitochondrial quantity and quality in skeletal muscle. Mitochondrial dynamics, the coordination of fission and fusion events, are poised to mediate key aspects of organelle adaptation that arise from exercise.
Elya J. Ritenis, Christos G. Stathis, Matthew B. Cooke, Stephen Keenan, Andrew Philp, Donny M. Camera   +5 more
wiley   +1 more source

Multifaceted roles of arginine in cellular function, signaling, and disease. [PDF]

Front Chem
Mehmood T, Ali M, Javed M, Mateen RM, Nouman M, Knani S, Alreshidi R, Iqbal S.   +7 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source