Results 191 to 200 of about 41,822 (243)

Small GTP-binding proteins and their regulators in cardiac hypertrophy

Journal of Molecular and Cellular Cardiology, 2008
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank, Lezoualc'h, Mélanie, Métrich, Isabelle, Hmitou, Nicolas, Duquesnes, Eric, Morel   +4 more
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Tumour suppressors and the regulation of GTP-binding protein activity

Trends in Cell Biology, 1993
GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
I, Rey, A, Hall
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DRG: A novel developmentally regulated GTP-binding protein

Biochemical and Biophysical Research Communications, 1992
Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
T, Sazuka, Y, Tomooka, Y, Ikawa, M, Noda, S, Kumar   +4 more
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Regulation of Protein Trafficking by GTP-Binding Proteins

2009
In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
Michel Franco, Philippe Chavrier, Florence Niedergang   +2 more
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Regulation of vesicular transport by GTP-binding proteins

Current Opinion in Nephrology and Hypertension, 1995
Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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Distribution and Regulation of RAB3C, a Small Molecular Weight GTP-Binding Protein

Biochemical and Biophysical Research Communications, 1994
We have investigated the expression and regulation of rab3C in rat tissues and rat pheochromocytoma PC12 cells by using a polyclonal antibody that specifically recognizes this protein. Rab3C was expressed in the neuroendocrine systems, as is its highly homologous family member, rab3A.
Y C, Su, L S, Kao, Y Y, Chu, Y, Liang, M H, Tsai, Y, Chern   +5 more
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Cellular responses regulated by rho-related small GTP-binding proteins

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
A, Hall, H F, Paterson, P, Adamson, A J, Ridley   +3 more
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Regulation of the phagocyte respiratory burst by small GTP-binding proteins

Trends in Cell Biology, 1995
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
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The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast Function

Calcified Tissue International, 2003
The Ras superfamily of small GTP-binding proteins (also known as small GTPases) comprises more than 80 highly conserved proteins of the Ras, Rho, and Rab subfamilies that are involved in multiple intracellular signalling pathways. These proteins are able to function as molecular switches in the transduction of signals from membrane receptors by cycling
F P, Coxon, M J, Rogers
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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins

Journal of Microscopy, 2008
SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
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