Results 211 to 220 of about 82,021 (288)

Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early <i>Legionella</i> infection. [PDF]

open access: yesProc Natl Acad Sci U S A
Im HN   +11 more
europepmc   +1 more source

Engineered interfaces in Rac1 and Cdc42 biosensors enhance sensitivity and reduce cell perturbation. [PDF]

open access: yesMol Biol Cell
Marston DJ   +10 more
europepmc   +1 more source

The cytokinesis regulator RacGAP1 is a Rac1-specific GAP on membranes. [PDF]

open access: yesProtein Sci
Dubois P   +5 more
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

open access: yesAdvanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin   +11 more
wiley   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun   +11 more
wiley   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

open access: yesAdvanced Science, Volume 13, Issue 26, 8 May 2026.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang   +12 more
wiley   +1 more source

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