Advanced Science, Volume 13, Issue 50, 7 September 2026.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
Stanniocalcin-1 Attenuates Cardiac Fibrosis Post Ischemia-Reperfusion Injury by Targeting the DOCKER Domain of Dedicator of Cytokinesis 1. [PDF]
J Am Heart AssocWang X +5 more
europepmc +1 more source
Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models
Arthritis &Rheumatology, Volume 78, Issue 9, Page 1942-1951, September 2026.Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis +11 more
wiley +1 more source
RAC1 regulates Sonic Hedgehog-medulloblastoma growth via GLI-mediated transcription. [PDF]
Neuro OncolJangde N +11 more
europepmc +1 more source
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
IQGAP3, the overlooked oncogenic twin of IQGAP1: mapping its interactome and functional roles across cellular signaling and cancer. [PDF]
Cell Commun SignalBasu S, Dixit M.
europepmc +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang +5 more
wiley +1 more source
Molecular mechanisms of ANKH function and regulation in skeletal mineralization. [PDF]
JBMR PlusWathuliyadde N, Willmore KE, Kelly GM.
europepmc +1 more source
Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska +5 more
wiley +1 more source
Epigenetics in Atrial Fibrillation: Molecular Mechanisms and Therapeutic Avenues. [PDF]
Rev Cardiovasc MedLiu X +5 more
europepmc +1 more source