Results 221 to 230 of about 82,021 (288)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen   +15 more
wiley   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, Volume 13, Issue 29, 22 May 2026.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Disabling posttranscriptional regulation of AGO2 results in enhanced viral resistance

open access: yes
New Phytologist, Volume 250, Issue 6, Page 3534-3539, June 2026.
Márta Ludman, Károly Fátyol
wiley   +1 more source

Systematic and precise interventions for KRAS-mutant cancers. [PDF]

open access: yesExp Hematol Oncol
Liang J   +5 more
europepmc   +1 more source

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