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Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Extra-large G proteins and their roles in plant development and responses to environmental stresses. [PDF]

Front Plant Sci
Meshram S, Akintayo OF, Bhattacharyya MK.   +2 more
europepmc   +1 more source

Oligomerization-dependent and synergistic regulation of Cdc42 GTPase cycling by a GEF and a GAP. [PDF]

EMBO Rep
Tschirpke S, Daalman WK, van Opstal F, Laan L.   +3 more
europepmc   +1 more source

Rab5 nucleotide binding promotes oxidative metabolism to fuel hepatocellular carcinoma cell proliferation. [PDF]

J Biol Chem
Otakhor KO, Zaidi MAA, Oberley-Deegan RE, Ponnusamy MP, Fisher KW, Schott MB.   +5 more
europepmc   +1 more source

Mechanistic Links Between DNA Methylation and Protein Translation and Their Impacts on Brain Development. [PDF]

Biology (Basel)
Kadar Shahib A, Rastegar M.
europepmc   +1 more source

Mammalian evolution and human mutation burden in Rab GTPases. [PDF]

Biochem Biophys Rep
Sidor U, Hughes GM, Simpson JC.
europepmc   +1 more source

Sensing centrosome amplification: the interface between centriole duplication and autophagy. [PDF]

Nat Commun
Coelho PA, Fatalska A, Geymonat M, Lattao R, Glover DM.   +4 more
europepmc   +1 more source

Small GTP-binding proteins in the regulation of exocytosis in mast cells

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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation

Biochemical and Biophysical Research Communications, 2021
Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Byong Seo Park, Hye Li Im, Nal Ae Yoon, Thai Hien Tu, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee   +6 more
openaire   +2 more sources