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Phosphorylation at S1288 of leukemia associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA. [PDF]
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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation
Biochemical and Biophysical Research Communications, 2021Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Byong Seo Park +6 more
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Regulation of small GTP-binding proteins by insulin
Biochemical Society Transactions, 2006Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
G I, Welsh +3 more
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Small GTP-binding proteins and their regulators in cardiac hypertrophy
Journal of Molecular and Cellular Cardiology, 2008Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank, Lezoualc'h +4 more
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Tumour suppressors and the regulation of GTP-binding protein activity
Trends in Cell Biology, 1993GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
I, Rey, A, Hall
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DRG: A novel developmentally regulated GTP-binding protein
Biochemical and Biophysical Research Communications, 1992Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
T, Sazuka +4 more
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Regulation of vesicular transport by GTP-binding proteins
Current Opinion in Nephrology and Hypertension, 1995Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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Regulation of Protein Trafficking by GTP-Binding Proteins
2009In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
Michel Franco +2 more
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