Results 241 to 250 of about 4,439,363 (293)

Regulation of small GTP-binding proteins by insulin

Biochemical Society Transactions, 2006
Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
G I, Welsh, I, Hers, M, Wherlock, J M, Tavaré   +3 more
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Tumour suppressors and the regulation of GTP-binding protein activity

Trends in Cell Biology, 1993
GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
I, Rey, A, Hall
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Small GTP-binding proteins and their regulators in cardiac hypertrophy

Journal of Molecular and Cellular Cardiology, 2008
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank, Lezoualc'h, Mélanie, Métrich, Isabelle, Hmitou, Nicolas, Duquesnes, Eric, Morel   +4 more
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DRG: A novel developmentally regulated GTP-binding protein

Biochemical and Biophysical Research Communications, 1992
Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
T, Sazuka, Y, Tomooka, Y, Ikawa, M, Noda, S, Kumar   +4 more
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Regulation of Protein Trafficking by GTP-Binding Proteins

2009
In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
Michel Franco, Philippe Chavrier, Florence Niedergang   +2 more
openaire   +1 more source

Regulation of vesicular transport by GTP-binding proteins

Current Opinion in Nephrology and Hypertension, 1995
Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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Cellular responses regulated by rho-related small GTP-binding proteins

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
A, Hall, H F, Paterson, P, Adamson, A J, Ridley   +3 more
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The regulation of mitochondrial physiology by organelle‐associated GTP‐binding proteins

Cell Biochemistry and Function, 2002
AbstractRecent studies have shown that GTP‐binding proteins can modulate mitochondrial membrane fusion and fission. Furthermore, GTP‐binding proteins can regulate the binding of ribosomes to the mitochondrial membrane and may facilitate the import of proteins through contact points between inner and outer mitochondrial membranes.
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Regulation of the phagocyte respiratory burst by small GTP-binding proteins

Trends in Cell Biology, 1995
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
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Distribution and Regulation of RAB3C, a Small Molecular Weight GTP-Binding Protein

Biochemical and Biophysical Research Communications, 1994
We have investigated the expression and regulation of rab3C in rat tissues and rat pheochromocytoma PC12 cells by using a polyclonal antibody that specifically recognizes this protein. Rab3C was expressed in the neuroendocrine systems, as is its highly homologous family member, rab3A.
Y C, Su, L S, Kao, Y Y, Chu, Y, Liang, M H, Tsai, Y, Chern   +5 more
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