Results 181 to 190 of about 81,307 (285)

Direct crosstalk between GPCRs and ion channels via G proteins. [PDF]

Exp Mol Med
Kim SH, Kim J, So I, Lee HH.
europepmc   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Systematic and precise interventions for KRAS-mutant cancers. [PDF]

Exp Hematol Oncol
Liang J, Wu J, Zhang Y, Wang H, Zheng Y, He Q.   +5 more
europepmc   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B. [PDF]

Nat Commun
Duhay V, Tian M, Kosieradzka K, Ebner M, Lo WT, Krauss M, Sprengel HL, Voss M, Riechmann M, Savas JN, Schwake M, Haucke V, Damme M.   +12 more
europepmc   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Phosphorylation at S1288 of leukemia associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA. [PDF]

J Biol Chem
Yang WS, Ghanem NZ, Scahill SD, Caliva MJ, Röttig H, Fitz A, Matter ML, Ramos JW.   +7 more
europepmc   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Where and how many: evolutionary diversification of a molecular switch regulating flagellar patterns. [PDF]

J Bacteriol
Bange G, Hochberg G, Thormann K, Dornes A.   +3 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source