Results 181 to 190 of about 104,548 (291)

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, EarlyView.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling. [PDF]

Protein Sci
Jabbar J, Afroze B, Ling NXY, Oakhill JS, Rouiller I.   +4 more
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

EZR-PLC and RhoGTPases interactions in osteosarcoma pathogenesis and metastatic process [PDF]

, 2014
LEOPIZZI, MARTINA
core   +1 more source

Asgard Arf GTPases can act as membrane-associating molecular switches with the potential to function in organelle biogenesis. [PDF]

Nat Commun
Zhu J, Xie R, Ren Q, Zhou J, Chen C, Xie MX, Zhou Y, Zhang Y, Liu N, Wang J, Zhang Z, Liu X, Yan W, Gong Q, Dong L, Zhu J, Wang F, Xie Z.   +17 more
europepmc   +1 more source

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network. [PDF]

Proc Natl Acad Sci U S A
Yoshimura SI, Sobajima T, Kunii M, Harada A.   +3 more
europepmc   +1 more source

Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization

The FEBS Journal, EarlyView.
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun, So Young Lee, Shin‐Young Park, Joong Sub Choi, Mee‐Sup Yoon, Joong‐Soo Han   +5 more
wiley   +1 more source

Microtubule plus-end tracking protein EB1 orchestrates mitotic progression via liquid-liquid phase separation. [PDF]

J Mol Cell Biol
Li M, Dai M, Hong X, Li Y, Wang X, Lin Y, Ullah T, Zhu Y, Jiang K, Wang Z, Hou Z, Zhang K, Yao X, Song X, Liu X.   +14 more
europepmc   +1 more source

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

The FEBS Journal, EarlyView.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang, Noah J. Levi, Maykelis Diaz‐Solares, Carsten Mim, Gerhard Dahl, Rene Barro‐Soria   +5 more
wiley   +1 more source