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Small GTP-binding proteins and their regulators in cardiac hypertrophy

open access: closedJournal of Molecular and Cellular Cardiology, 2008
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank Lezoualc’h   +4 more
openalex   +3 more sources
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Regulation of Protein Trafficking by GTP-Binding Proteins

, 2009
In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
M. Franco, P. Chavrier, F. Niedergang
semanticscholar   +2 more sources

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