The GTP-binding protein, Go, regulates neuronal calcium channels.
Nature, 1987In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has yet been demonstrated.
J, Hescheler +3 more
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Regulation of the phagocyte respiratory burst by small GTP-binding proteins
Trends in Cell Biology, 1995Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Journal of Microscopy, 2008SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
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Common Properties of Receptors Coupled to GTP Binding Regulator Proteins
1989A number of membrane receptors coupled to GTP binding regulatory proteins have recently been shown to share structural propertie at the level both of the genes and of the corresponding proteins (Fig. 1 and 2). By comparing results obtained for α2-, β1- and β2-adrenergic catecholamine receptors, M1 to M5 muscarinic acetylcholine receptors as well as ...
L. Emorine +6 more
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Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins
Current Opinion in Cell Biology, 1996Integrin signalling requires the activation of protein tyrosine kinases and members of the Rho family of small GTP-binding proteins. Recent evidence shows that coordinated regulation of these signalling molecules is central to the control of cell adhesion, formation of the actin cytoskeleton and activation of intracellular signalling cascades.
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Highlight: GTP Binding Proteins Central Regulators in Cell Biology
Biological Chemistry, 2000Wittinghofer, A., Gierschik, P.
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The GTP-binding protein, Go9 regulates neuronal calcium channels
Nature, 1987J. Hescheler +3 more
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Regulation of Rod GTP Binding Protein by Guanine Nucleotides1
The Journal of Biochemistry, 1984Hitoshi SHICHI, Robert L. SOMERS
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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