Results 251 to 260 of about 149,249 (343)

Genetic code expansion and enzymatic modifications as accessible methods for studying site‐specific post‐translational modifications of alpha‐synuclein and tau

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Alpha‐synuclein (αS) and tau play important roles in the pathology of Parkinson's disease and Alzheimer's disease, respectively, as well as numerous other neurodegenerative diseases. Both proteins are classified as intrinsically disordered proteins (IDPs), as they have no stable structure that underlies their function in healthy tissue, and ...
Ibrahim G. Saleh, Marie Shimogawa, Jennifer Ramirez, Bernard Abakah, Yarra Venkatesh, Honey Priya James, Ming‐Hao Li, Sarah A. Louie, Marshall G. Lougee, Wai‐Kit Chia, Christopher Brue, Richard B. Cooley, Ryan A. Mehl, Tobias Baumgart, Robert H. Mach, David Eliezer, Elizabeth Rhoades, E. James Petersson   +17 more
wiley   +1 more source

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gα_o is disrupted by Gα_o encephalopathy variants. [PDF]

J Biol Chem
Momplaisir NL, Chandan NR, Wang B, Qu E, Smrcka AV.   +4 more
europepmc   +1 more source

Genomic Characterisation of Limosilactobacillus fermentum CRL2085 Unveiling Probiotic Traits for Application in Cattle Feed

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
A comprehensive genomic and phenotypic analysis of Limosilactobacillus fermentum CRL2085 revealed key probiotic and nutritional traits supporting its safe application in cattle feed. The strain harbors genes for stress tolerance, adhesion, exopolysaccharide production, and B‐vitamin biosynthesis, and efficiently metabolizes plant‐derived carbohydrates,
Cecilia M. Aristimuño Ficoseco, Daniele Chieffi, Marco Montemurro, Annarita Bavaro, Carlo G. Rizzello, Maria E. F. Nader‐Macias, Silvina Fadda, Francesca Fanelli, Vincenzina Fusco, Graciela M. Vignolo   +9 more
wiley   +1 more source

Nuclear-activating miRNAs: unveiling the intricacies of subcellular miRNA function and regulation in cancer and immunity disease. [PDF]

Cancer Cell Int
Ren X, Liu G, Zhou J.
europepmc   +1 more source

New insights into tuberous sclerosis complex: from structure to pathogenesis. [PDF]

Front Cell Dev Biol
Chen CS, Aylett CHS.
europepmc   +1 more source

Late blight pathogen targets host Rab-G3 GTPases with an atypical GTPase-activating protein. [PDF]

J Integr Plant Biol
Liu S, Ding L, Liu X, Xing X, Li J, Yan T, Huang Y, Liu Y, Wang Y, Zhang X, Liu Z, Cao X, Meng Y, Shan W.   +13 more
europepmc   +1 more source

Chemical biology approaches to resolve the subcellular GPCR signaling landscape. [PDF]

Nat Chem Biol
Bock A, Lobingier BT, Stoeber M, Tsvetanova NG.   +3 more
europepmc   +1 more source

RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer's Disease. [PDF]

Curr Issues Mol Biol
Medd MM, Yon JE, Dong H.
europepmc   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer. [PDF]

Adv Sci (Weinh)
Yan Y, Wang N, Xing B, Yang M, Shang J, Bao Y, Xiao L, Zhang N, Ren Y, Liu C, Chen Y, Han H, Pan Y, Lv L, Zong WX, Ji H, Zhan C, Wang Z, Chen H, Wang Y.   +19 more
europepmc   +1 more source