Results 251 to 260 of about 80,664 (305)
Some of the next articles are maybe not open access.
DRG: A novel developmentally regulated GTP-binding protein
Biochemical and Biophysical Research Communications, 1992Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
Makoto Noda +4 more
openaire +3 more sources
The GTP-binding protein, Go9 regulates neuronal calcium channels
Nature, 1987In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has yet been demonstrated.
Günter Schultz +3 more
openaire +3 more sources
Regulation of vesicular transport by GTP-binding proteins
Current Opinion in Nephrology and Hypertension, 1995Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
openaire +4 more sources
Regulation of Protein Trafficking by GTP-Binding Proteins
2009In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
Florence Niedergang +2 more
openaire +2 more sources
Distribution and Regulation of RAB3C, a Small Molecular Weight GTP-Binding Protein
Biochemical and Biophysical Research Communications, 1994We have investigated the expression and regulation of rab3C in rat tissues and rat pheochromocytoma PC12 cells by using a polyclonal antibody that specifically recognizes this protein. Rab3C was expressed in the neuroendocrine systems, as is its highly homologous family member, rab3A.
Lung-Sen Kao +5 more
openaire +3 more sources
Regulation of phagocyte function by low molecular weight GTP‐binding proteins [PDF]
European Journal of Haematology, 1993 Abstract: The mechanisms used by phagocytic leukocytes in the process of bacterial killing are regulated by GTP‐binding proteins of the Ras superfamily. In particular, the formation of toxic oxygen metabolites via the NADPH oxidase requires the action of both Rac and Rap1A proteins.
openaire +2 more sources
Cellular responses regulated by rho-related small GTP-binding proteins
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
Peter Adamson +3 more
openaire +3 more sources
Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Journal of Microscopy, 2008SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
openaire +3 more sources
The regulation of mitochondrial physiology by organelle‐associated GTP‐binding proteins
Cell Biochemistry and Function, 2002AbstractRecent studies have shown that GTP‐binding proteins can modulate mitochondrial membrane fusion and fission. Furthermore, GTP‐binding proteins can regulate the binding of ribosomes to the mitochondrial membrane and may facilitate the import of proteins through contact points between inner and outer mitochondrial membranes.
openaire +3 more sources
The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast Function
Calcified Tissue International, 2003The Ras superfamily of small GTP-binding proteins (also known as small GTPases) comprises more than 80 highly conserved proteins of the Ras, Rho, and Rab subfamilies that are involved in multiple intracellular signalling pathways. These proteins are able to function as molecular switches in the transduction of signals from membrane receptors by cycling
Michael J. Rogers, Fraser P. Coxon
openaire +2 more sources