Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. [PDF]
, 2012 Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes.
Cascio, Duilio +5 more
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GTP Binding Assays in Arabidopsis thaliana
Bio-Protocol, 2013 Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
doaj +1 more source
GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential. [PDF]
PLoS ONE, 2012 ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases. All three ARL4 proteins contain nuclear localization signals (NLSs) at their C-termini and are primarily found at the plasma ...
Chun-Chun Li +7 more
doaj +1 more source
Essential Role of the G-Domain in Targeting of the Protein Import Receptor atToc159 to the Chloroplast Outer Membrane [PDF]
, 2002 Two homologous GTP-bindin proteins, atToc33 and atToc159, control access of cytosolic precursor proteins to the chloroplast, at Toc33 is a constitutive outer chloroplast membrane protein, whereas the precusor receptor atToc159 may be able to switch ...
Alvarez-Huerta, Mayte +7 more
core +3 more sources
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. [PDF]
PLoS ONE, 2011 Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain.
Jean-Marc Taymans +7 more
doaj +1 more source
Involvement of a small GTP binding protein in HIV-1 release
Retrovirology, 2005 Background There is evidence suggesting that actin binding to HIV-1 encoded proteins, or even actin dynamics themselves, might play a key role in virus budding and/or release from the infected cell.
Gluschankof Pablo +2 more
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The Targeting of the atToc159 Preprotein Receptor to the Chloroplast Outer Membrane is Mediated by its GTPase Domain and is Regulated by GTP [PDF]
, 2002 The multimeric translocon at the outer envelope membrane of chloroplasts (Toc) initiates the recognition and import of nuclear-encoded preproteins into chloroplasts.
Hiltbrunner, Andreas +3 more
core +2 more sources
eLife, 2023 Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system ...
Thomas-O Peulen +15 more
doaj +1 more source
Nucleotide binding switches the information flow in ras GTPases.
PLoS Computational Biology, 2011 The Ras superfamily comprises many guanine nucleotide-binding proteins (G proteins) that are essential to intracellular signal transduction. The guanine nucleotide-dependent intrinsic flexibility patterns of five G proteins were investigated in atomic ...
Francesco Raimondi +3 more
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Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]
, 2017 [FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura +8 more
core +1 more source