Results 231 to 240 of about 232,963 (342)

Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution. [PDF]

Elife
Merino-Salomón A, Scheneider J, Babl L, Krohn JH, Sobrinos-Sanguino M, Schaefer T, Luque-Ortega JR, Alfonso C, Jiménez M, Jasnin M, Schwille P, Rivas G.   +11 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Identification of the client-binding site on the Golgi membrane protein adaptor Vps74/yGOLPH3. [PDF]

iScience
Lesniak AM, Ye Z, Banfield DK.
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Investigation of the Substrate Selection Mechanism of Poly (A) Polymerase Based on Molecular Dynamics Simulations and Markov State Model. [PDF]

Int J Mol Sci
Jiang Y, Duan X, Zheng J, Cao F, Zeng L, Han W.   +5 more
europepmc   +1 more source

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

, 1990
Philippe Chavrier, Robert G. Parton, Hans Peter Hauri, Kai Simons, Marino Zerial   +4 more
openalex   +1 more source

Putative GTP-Binding Protein, Gtr1, Associated with the Function of the Pho84 Inorganic Phosphate Transporter in Saccharomyces cerevisiae [PDF]

, 1992
Masanori Bun‐ya, Satoshi Harashima, Yasuji Oshima   +2 more
openalex   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Michaelis-Menten kinetics of RasGAP proteins by a rapid fluorescence-based assay. [PDF]

Methods
Paul ME, Vish KJ, Boggon TJ.
europepmc   +1 more source

Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins.

, 1990
Meir Aridor, Linton M. Traub, Ronit Sagi‐Eisenberg   +2 more
openalex   +1 more source