Results 91 to 100 of about 68,431 (214)

Research progress in ferroptosis regulation in the treatment of liver diseases

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Ferroptosis is a form of cell death that results from accumulation of lipid reactive oxygen species, marked by iron-dependent oxidative damage of phospholipids. Accumulation of iron and lipid hydroperoxides are hallmarks of ferroptosis.
CHEN Chen, CHENG Zhuoan, WANG Cun, XIA Qiang   +3 more
doaj   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle, Agarwal, Agrawal, Aladin, Anderson, Andersson, Annunen, Arnold, Ashford, Atkinson, Bandell, Battie, Battie, Bautista, Bejaoui, Berthele, Beyer, Blau, Bond, Brown, Brown, Brown, Campa, Caraco, Carbonell Sala, Carragee, Cascorbi, Cho, Chou, Chou, Cipollone, Collart, Cox, Dalen, Daly, Dawkins, Dayer, Dayer, Diatchenko, Diatchenko, Diatchenko, Dick, Doehring, Eckhardt, Einarsdottir, Fillingim, Foulkes, Fu, Gasche, Goldberg, Grant, Gross, Gursoy, Gutierrez-Roelens, Hamdani, Hartvigsen, Hayashida, Hernandez, Higashino, Hirose, Hoyland, Hummel, Hustmyer, Ikeda, Indo, Irmgard Tegeder, Jayamanne, Jim, Jörn Lötsch, Kales, Kalichman, Karppinen, Karsak, Kawaguchi, Kawaguchi, Kawasaki, Khoromi, Kim, Kim, Kim, Kim, Kirchheiner, Kirchheiner, Klepstad, Knoeringer, Kroslak, Kuisma, Kung, Lafreniere, Landau, Langdahl, Le Maitre, Lee, Lettre, Leyne, Lichtman, Liem, Lorenzo, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lotsch, Lovlie, Lu, Luoma, Lötsch, MacDonald, Macpherson, Madadi, Manning, McNamara, Meeus, Meller, Meller, Mignat, Mio, Miura, Mogil, Mogil, Morrison, Nguyen, Noponen-Hietala, Noponen-Hietala, Oakley, Oertel, Oertel, Oertel, Ofek, Ohtori, Oliveira, Paassilta, Papafili, Pilotto, Pluijm, Poulsen, Racz, Racz, Rakvag, Ralston, Ralston, Reyes-Gibby, Richards, Riviere, Roddier, Romberg, Russo, Sachse, Sakai, Schmidt, Schneider, Seki, Seki, Sindrup, Sipe, Skarke, Skarke, Slade, Slaugenhaupt, Solovieva, Solovieva, Solovieva, Solovieva, Solovieva, Srinivasan, Srinivasan, Stamer, Stamer, Steward, Stohler, Suzuki, Svendsen, Tadic, Takahashi, Tam, Tander, Tegeder, Tegeder, Thieme, Thomas, Trevisani, Uitterlinden, Ujike, van Meurs, Vargas-Alarcon, Verhoeven, Videman, Videman, Virtanen, Voronov, Vree, Wiesinger, Yamada, Yazdanpanah, Zhang, Zhang, Zhang, Zhang, Zubieta, Zuo   +200 more
core   +1 more source

Elderly Liver Grafts are More Susceptible to Ischemia‐Reperfusion After Prolonged Cold Ischemia than Grafts from Young Donors—An Ex Vivo Liver Machine Perfusion Analysis in Sprague Dawley Rats

Advanced Therapeutics, Volume 8, Issue 12, December 2025.
This study investigates how donor age and cold ischemia time influence liver perfusion parameters and injury markers. Older livers are more susceptible to longer ischemia times displaying more tissue damage, and higher expression of oxidative stress and apoptosis‐related proteins than livers with shorter ischemia times.
Leonard Boerger, Kilian A. Walter, Anna S. Pietsch, Linda Gilles, Oliver Klein, Karl H. Hillebrandt, Joseph M. G. V. Gassner, Jasper Iske, Johann Pratschke, Felix Krenzien, Igor M. Sauer, Nathanael Raschzok, Simon Moosburner   +12 more
wiley   +1 more source

Functional Promiscuity of the COG0720 Family [PDF]

, 2011
The biosynthesis of GTP derived metabolites such as tetrahydrofolate (THF), biopterin (BH4), and the modified tRNA nucleosides queuosine (Q) and archaeosine (G+) relies on several enzymes of the Tunnel-fold superfamily. A subset of these proteins include
Bailly, Marc, Bonnett, Shilah, de Crécy-Lagard, Valérie, El Yacoubi, Basma, Grochowski, Laura L., Haas-Blaby, Crysten, Iwata-Reuyl, Dirk, Phillips, Gabriela, White, Robert H., Xu, Huimin   +9 more
core   +2 more sources

Statin Increases GTP Cyclohydrolase I mRNA and 5,6,7,8-Tetrahydrobiopterin in Vascular Endothelial Cells

Pteridines, 2006
We investigated the effects of HMG-CoA reductase inhibitors, so-called statins, on 5,6,7,8-tctrahydrobioptcrin (BH4) metabolism in human umbilical vein endothelial cells (HUVEC).
Hattori Yoshiyuki, Nakanishi Nobuo
doaj   +1 more source

Genetic diagnosis of two dopa-responsive dystonia families by exome sequencing. [PDF]

PLoS ONE, 2014
Dopa-responsive dystonia, a rare disorder typically presenting in early childhood with lower limb dystonia and gait abnormality, responds well to levodopa. However, it is often misdiagnosed with the wide spectrum of phenotypes.
Zhan-fang Sun, Yu-han Zhang, Ji-feng Guo, Qi-ying Sun, Jun-pu Mei, Han-lin Zhou, Li-ping Guan, Jin-yong Tian, Zheng-mao Hu, Jia-da Li, Kun Xia, Xin-xiang Yan, Bei-sha Tang   +12 more
doaj   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Food Fortification: Strategy to Combat Hidden Hunger: A Systematic Review

Food Chemistry International, Volume 1, Issue 4, Page 384-407, December 2025.
Food fortification involves adding essential vitamins and minerals (e.g., iron, iodine, vitamin A, and folic acid) to staple foods such as salt, wheat flour, rice, and oil. ABSTRACT Hidden hunger or micronutrient deficiency, affects over two billion people worldwide, particularly in low‐ and middle‐income countries. This global problem impacts nearly a
Gaurav Chaudhary, Monu Kumar, Anita Rani Sehrawat   +2 more
wiley   +1 more source

Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis‐Related Biomarkers

Journal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2913-2924, December 2025.
ABSTRACT Background The efficacy of neoadjuvant chemotherapy (NAC) combined with surgery and postoperative adjuvant chemotherapy in improving the prognosis of locally advanced gastric cancer (LAGC) has been confirmed. Nevertheless, there is still no effective tool to predict the response to NAC in gastric cancer patients.
Minxuan Shen, Qinbo Cai, Rongchang Wang, Feiran Zhang, Huanjie Chen, Xiaoqun Wang, Rongman Xie, Jie Zhang, Baoyi Liu, Yulong He, Xun Hou, Dongjie Yang   +11 more
wiley   +1 more source

cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells

Journal of Pharmacological Sciences, 2003
: Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) catalysis of ...
Hiroaki Shiraishi, Taiya Kato, Koji Atsuta, Chiho Sumi-Ichinose, Masatsugu Ohtsuki, Mitsuyasu Itoh, Hitoshi Hishida, Shin Tada, Yasuhiro Udagawa, Toshiharu Nagatsu, Yasumichi Hagino, Hiroshi Ichinose, Takahide Nomura   +12 more
doaj   +1 more source