Results 121 to 130 of about 68,431 (214)

The Next Frontier in Parkinson's Disease Treatment: A Narrative Review of Innovative Neurosurgical and Gene Therapy Approaches

Health Science Reports, Volume 8, Issue 9, September 2025.
ABSTRACT Background and Aims Parkinson's disease (PD) is a progressive neurological condition that consists of both motor and non‐motor symptoms that considerably deteriorate the quality of life. Pharmacological treatments, primarily levodopa, have been used to manage PD. However, side effects such as dyskinesias and motor fluctuations frequently limit
Muhammad Shaheer Bin Faheem, Muhammad Haroon‐Ul‐Rasheed, Rohma Aftab, Qasra Faheem, Faheem Feroze, Hafiza Qurat Ul Ain, Sumaya Samadi   +6 more
wiley   +1 more source

Novel genomic island modifies DNA with 7-deazaguanine derivatives [PDF]

, 2015
The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ[subscript 0]) synthesis and DNA metabolism genes, led to the hypothesis that 7 ...
Brochier-Armanet, Celine, de Crécy-Lagard, Valérie, Dedon, Peter C, Hillebrand, Roman, Hutinet, Geoffrey, Jumpathong, Watthanachai, Kellner, Stefanie M, Letarov, Andrey V., Malik, Chanchal K., Mohapatra, Susovan, Rizzo, Carmelo J., Thiaville, Jennifer J., Thiaville, Patrick C., Yuan, Yifeng   +13 more
core   +1 more source

A novel missense mutation pattern of the GCH1 gene in dopa-responsive dystonia Novo padrão de mutação missense no gene GCH1 na distonia dopa-responsiva

Arquivos de Neuro-Psiquiatria, 2007
Dopa-responsive dystonia (DRD) is an inherited metabolic disorder now classified as DYT5 with two different biochemical defects: autosomal dominant GTP cyclohydrolase 1 (GCH1) deficiency or autosomal recessive tyrosine hydroxylase deficiency.
Rosana H. Scola, Carla Carducci, Vanise G. Amaral, Paulo J. Lorenzoni, Helio A.G. Teive, Teresa Giovanniello, Lineu C. Werneck   +6 more
doaj   +1 more source

Author Correction: Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Maria del Carmen Asensio Lopez, Antonio Lax, Alvaro Hernandez Vicente, Elena Saura Guillen, Antonio Hernandez-Martinez, Maria Josefa Fernandez del Palacio, Antoni Bayes-Genis, Domingo A. Pascual Figal   +7 more
doaj   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by 17β-Estradiol in Brain Microvascular Endothelial Cells

Pteridines, 2000
The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro, Ishii Masakazu, Yamamoto Toshinori, Shimizu Shunichi, Kiuchi Yuji   +4 more
doaj   +1 more source

Promiscuous and Adaptable Enzymes Fill “Holes” in the Tetrahydrofolate Pathway in Chlamydia Species

mBio, 2014
Folates are tripartite molecules comprising pterin, para-aminobenzoate (PABA), and glutamate moieties, which are essential cofactors involved in DNA and amino acid synthesis.
Nancy E. Adams, Jennifer J. Thiaville, James Proestos, Ana L. Juárez-Vázquez, Andrea J. McCoy, Francisco Barona-Gómez, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard, Anthony T. Maurelli   +8 more
doaj   +1 more source

In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH₄ Therapeutics. [PDF]

Int J Mol Sci, 2023
Hussein D.
europepmc   +1 more source

To what extent do structural changes in catalytic metal sites affect enzyme function? [PDF]

, 2017
About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold.
Andreini, Claudia, Furnham, Nicholas, Rosato, Antonio, Thornton, Janet M, Valasatava, Yana   +4 more
core   +2 more sources

Serotonergic system in vivo with [¹¹C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients. [PDF]

Sci Rep, 2022
Timmers ER, Peretti DE, Smit M, de Jong BM, Dierckx RAJO, Kuiper A, de Koning TJ, Vállez García D, Tijssen MAJ.   +8 more
europepmc   +1 more source

Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication [PDF]

, 2011
Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are visited by the protein also in the ...
Mitternacht, Simon, Berezovsky, Igor N.
core   +1 more source