The protein partners of GTP cyclohydrolase I in rat organs. [PDF]
PLoS ONE, 2012 GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis and diabetes.
Jianhai Du +6 more
doaj +2 more sources
Stem Cell Research, 2017 Fibroblasts from a female patient carrying a heterozygous variation in GTP cyclohydrolase 1 (GCH1; OMIM: 600225; HGNC: 4193; c.235_240del/p.(L79_S80del)), the rate-limiting enzyme of tetrahydrobiopterin (BH4) synthesis, were reprogrammed to iPSCs using ...
Sabine Jung-Klawitter +4 more
doaj +2 more sources
Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. [PDF]
Br J Pharmacol, 2015 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients.
Hussein D +8 more
europepmc +2 more sources
Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth. [PDF]
Oncotarget, 2016 Cancer-associated fibroblasts (CAFs) play a key role in promoting tumor growth, acting through complex paracrine regulation. GTP cyclohydrolase (GTPCH) expression for tetrahydrobiopterin synthesis in tumor stroma is implicated in angiogenesis and tumor ...
Chen L +11 more
europepmc +2 more sources
Lack of influence of GTP cyclohydrolase gene (
Molecular Pain, 2007 Objectives To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans. Methods Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers.
Dionne Raymond A, Kim Hyungsuk
doaj +3 more sources
Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock. [PDF]
Shock, 2014 Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH4) is an essential NOS cofactor.
Starr A +8 more
europepmc +2 more sources
GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus. [PDF]
PLoS One, 2014 Background The genetic background of atherosclerosis in type 2 diabetes mellitus (T2DM) is complex and poorly understood. Studying genetic components of intermediate phenotypes, such as endothelial dysfunction and oxidative stress, may aid in identifying
Wolkow PP +11 more
europepmc +2 more sources
Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance. [PDF]
Neuro Oncol, 2018 Tran AN +13 more
europepmc +2 more sources
Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB. [PDF]
Biochem J, 2017 Paranagama N +7 more
europepmc +2 more sources