Results 31 to 40 of about 68,431 (214)
Parkinsonism in GTP cyclohydrolase 1-deficient DOPA-responsive dystonia. [PDF]
Brain, 2015 Furukawa Y, Kish SJ.
europepmc +2 more sources
Reply: Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. [PDF]
Brain, 2015 Mencacci NE +6 more
europepmc +3 more sources
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation. [PDF]
Hypertension, 2014 Chuaiphichai S +7 more
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Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. [PDF]
PLoS ONE, 2011 Dystonia represents the third most common movement disorder in humans. At least 15 genetic loci (DYT1-15) have been identified and some of these genes have been cloned.
Noriko Wakabayashi-Ito +6 more
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GTP Cyclohydrolase II Structure and Mechanism [PDF]
Journal of Biological Chemistry, 2005 GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The essential role of riboflavin in metabolism and the absence of GTP cyclohydrolase II in higher eukaryotes makes it a potential novel selective antimicrobial drug target.
Ren J +5 more
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Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice. [PDF]
J Cardiovasc Pharmacol, 2014 dʼUscio LV, Santhanam AV, Katusic ZS.
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Atomic structure of GTP cyclohydrolase I [PDF]
Structure, 1995 Tetrahydrobiopterin serves as the cofactor for enzymes involved in neurotransmitter biosynthesis and as regulatory factor in immune cell proliferation and the biosynthesis of melanin. The biosynthetic pathway to tetrahydrobiopterin consists of three steps starting from GTP.
Nar, Herbert +5 more
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GTP cyclohydrolase I utilizes metal‐free GTP as its substrate [PDF]
European Journal of Biochemistry, 2003 GTP cyclohydrolase I (GCH) is the rate‐limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. We have studied the action of divalent cations on the enzyme activity of purified recombinant human GCH expressed in Escherichia ...
T. Suzuki, H. Kurita, H. Ichinose
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Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts
Bio-Protocol, 2014 Riboflavin is the precursor of flavin nucleotides FMN and FAD, they play significant roles in all organisms. GTP is the initial precursor on riboflavin biosynthesis pathway and GTP cyclohydrolase II catalyzes the first step of this pathway.
Svetlana Yurgel +3 more
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Molecular Plant-Microbe Interactions, 2021 Bradyrhizobium ORS285 forms a nitrogen-fixating symbiosis with both Nod factor (NF)-dependent and NF-independent Aeschynomene spp. The Bradyrhizobium ORS285 ribBA gene encodes for a putative bifunctional enzyme with 3,4-dihydroxybutanone phosphate (3,4 ...
Nico Nouwen +3 more
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