Journal of Pharmacological Sciences, 2005 We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and ...
Masakazu Ishii +7 more
doaj +1 more source
Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. [PDF]
PLoS ONE, 2012 GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in the de novo synthesis of tetrahydrobiopterin (BH4). GTPCH1 protein degradation has been reported in animal models of several diseases, including diabetes mellitus and hypertension. However, the
Yu Zhao, Huaiping Zhu, Ming-Hui Zou
doaj +1 more source
Structures and reaction mechanisms of GTP cyclohydrolases [PDF]
IUBMB Life, 2013 AbstractGTP cyclohydrolases generate the first committed intermediates for the biosynthesis of certain vitamins/cofactors (folic acid, riboflavin, deazaflavin, and tetrahydrobiopterin), deazapurine antibiotics, some t‐RNA bases (queuosine, archaeosine), and the phytotoxin, toxoflavin.
Tobias, Gräwert +2 more
openaire +2 more sources
Do Genetic Predictors of Pain Sensitivity Associate with Persistent Widespread Pain? [PDF]
, 2009 Genetic risk factors for pain sensitivity may also play a role in susceptibility to chronic pain disorders, in which subjects have low pain thresholds.
Kate L Holliday +6 more
core +1 more source
Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated GCH1 Region [PDF]
, 2013 Background: Mutations in the GCH1 gene are associated with childhood onset, dopa-responsive dystonia (DRD). Correct diagnosis of DRD is crucial, given the potential for complete recovery once treated with L-dopa.
Armata, Ioanna A. +10 more
core +2 more sources
Pteridines, 1995 Unconjugated pteridines are present in fungi, algae and plants. However, the functions of pteridines in these organisms are not thoroughly investigated. The biosynthesis follows the same steps as were shown for animals and eubacteria.
Maier Josef +2 more
doaj +1 more source
Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes [PDF]
Protein Science, 2001 AbstractGTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R‐l‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase.
T, Yoneyama, K, Hatakeyama
openaire +2 more sources
Discovering functional gene expression patterns in the metabolic network of with wavelets transforms [PDF]
, 2006 Background Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions. However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and ...
Zapatka Marc +7 more
core +2 more sources
A systematic map of genetic variation in Plasmodium falciparum.
PLoS Pathogens, 2006 Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health.
Claire Kidgell +13 more
doaj +1 more source
CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes
Diabetes, 2019 Endothelial dysfunction plays a crucial role in the progress of diabetic vasculopathy. C1q/tumor necrosis factor–related protein 13 (CTRP13) is a secreted adipokine that can ameliorate atherosclerosis and vascular calcification.
Cheng Wang +6 more
semanticscholar +1 more source