Results 81 to 90 of about 68,431 (214)
Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]
, 2011 Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin +4 more
core +1 more source
Pteridines, 2003 The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Dopa-responsive dystonia and hyperprolactinaemia : a novel association in two sisters [PDF]
, 2007 Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a "hereditary progressive basal ganglia disease with marked diurnal ...
Cachia, Mario J., Galea, Janabel
core
Evolution of pigment synthesis pathways by gene and genome duplication in fish [PDF]
, 2007 Background Coloration and color patterning belong to the most diverse phenotypic traits in animals. Particularly, teleost fishes possess more pigment cell types than any other group of vertebrates.
Ingo Braasch +2 more
core +1 more source
Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism
Pteridines, 1998 The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi +2 more
doaj +1 more source
Frontiers in Microbiology, 2022 Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) is the limiting enzyme of the tetrahydrobiopterin (BH4) synthesis pathway. The disruption of gch1 gene may cause conditional lethality due to folic acid auxotrophy in microorganisms, although the ...
Nan Tao +20 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 1, January 2026.Metabolomics‐based analysis of SAE mice by brain‐gut axis found that metabolic pathway analysis indicates that these differential metabolites are mainly involved in the metabolism of linoleic acid, biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism in the brain.
Yu Ke +8 more
wiley +1 more source
Pteridines, 2000 We investigated the effects of troglitazone, which is a ligand of nuclear transcription factor peroxisome proliferator- activated receptor-γ (PPAR-γ), on insulin-induced tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells ...
Ishii Masakazu +4 more
doaj +1 more source
NADPH‐Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry
Biochemistry Research International, Volume 2026, Issue 1, 2026.During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)–scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH), which is regulated by specific metabolic enzymes, which are
Camila M. Scudeler +7 more
wiley +1 more source